Detalles MARC
| 000 -CABECERA |
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05365nam a22003735i 4500 |
| 001 - NÚMERO DE CONTROL |
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233927 |
| 003 - IDENTIFICADOR DEL NÚMERO DE CONTROL |
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ES-VaUE |
| 005 - FECHA Y HORA DE LA ÚLTIMA TRANSACCIÓN |
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20221220020531.0 |
| 007 - CAMPO FIJO DE DESCRIPCIÓN FÍSICA--INFORMACIÓN GENERAL |
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cr nn 008mamaa |
| 008 - DATOS DE LONGITUD FIJA--INFORMACIÓN GENERAL |
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180321s2018 xxu| s |||| 0|eng d |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
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| Número Internacional Estándar del Libro |
9781493976775 |
| 024 7# - IDENTIFICADOR DE OTROS ESTÁNDARES |
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| Número estándar o código |
10.1007/978-1-4939-7677-5 |
| Fuente del número o código |
doi |
| 040 ## - FUENTE DE LA CATALOGACIÓN |
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| Centro catalogador/agencia de origen |
ES-MaUEC |
| Lengua de catalogación |
spa |
| Centro/agencia transcriptor |
ES-MaUEC |
| 245 10 - MENCIÓN DE TÍTULO |
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| Título |
Drug-Induced Liver Toxicity |
| Mención de responsabilidad, etc. |
edited by Minjun Chen, Yvonne Will. |
| 250 ## - MENCIÓN DE EDICIÓN |
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| Mención de edición |
1st edition 2018 |
| 264 #1 - PRODUCCIÓN, PUBLICACIÓN, DISTRIBUCIÓN, FABRICACIÓN Y COPYRIGHT |
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| Producción, publicación, distribución, fabricación y copyright |
New York, NY |
| Nombre del de productor, editor, distribuidor, fabricante |
Springer International Publishing |
| Fecha de producción, publicación, distribución, fabricación o copyright |
2018 |
| 300 ## - DESCRIPCIÓN FÍSICA |
|---|
| Extensión |
1 recurso en línea (XX, 667 páginas) |
| Otras características físicas |
119 ilustraciones, 70 ilustraciones a color |
| 336 ## - TIPO DE CONTENIDO |
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| Término de tipo de contenido |
texto |
| Código de tipo de contenido |
txt |
| Fuente |
rdacontent |
| 337 ## - TIPO DE MEDIO |
|---|
| Nombre/término del tipo de medio |
electrónico |
| Código del tipo de medio |
c |
| Fuente |
rdamedia |
| 338 ## - TIPO DE SOPORTE |
|---|
| Nombre/término del tipo de soporte |
recurso electrónico |
| Código del tipo de soporte |
cr |
| Fuente |
rdacarrier |
| 347 ## - CARACTERÍSTICAS DEL ARCHIVO DIGITAL |
|---|
| Tipo de archivo |
archivo de texto |
| Formato de codificación |
PDF |
| 490 0# - MENCIÓN DE SERIE |
|---|
| Mención de serie |
Methods in Pharmacology and Toxicology |
| Número Internacional Normalizado para Publicaciones Seriadas |
1940-6053 |
| 505 0# - NOTA DE CONTENIDO CON FORMATO |
|---|
| Nota de contenido con formato |
Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research -- Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery -- Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction -- Physicochemical Properties and Structural Alerts -- Quantitative Structure-Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans -- An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury -- Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities -- Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury -- Evaluation of Drug-induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches -- Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing -- Engineered Human Liver Co-Cultures for Investigating Drug-Induced Liver Injury -- Status and Future of 3D Cell Culture in Toxicity Testing -- Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design -- In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury -- Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches -- High Content Screening for Prediction of Human Drug-Induced Liver Injury -- Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge -- Perspectives on the Regulatory and Clinical Science of Drug-Induced Liver Injury (DILI) -- Regulatory Toxicological Studies: Identifying Drug-Induced Liver Injury Using Nonclinical Studies -- Hy's Law and eDISH for Clinical Studies -- Variability in Baseline Liver Test Values in Clinical Trials: Challenges in Enhancing Drug-Induced Liver Injury Assessment in Subjects with Liver Disease -- Postmarketing Surveillance of Drug-Induced Liver Injury -- Host Risk Modifiers in Idiosyncratic Drug-Induced Liver Injury (DILI) and Its Interplay with Drug Properties -- Human Leukocyte Antigen (HLA) and Other Genetic Risk Factors in Drug-Induced Liver Injury (DILI) -- Immune Mechanisms in Drug-Induced Liver Injury -- Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury -- Causality Assessment Methods in Drug-Induced Liver Injury -- Circulating MicroRNAs as Novel Biomarkers of Drug-Induced Liver Injury in Humans -- Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI) -- Non-Invasive Pre-Clinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury. |
| 520 ## - SUMARIO, ETC. |
|---|
| Sumario, etc. |
This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com. . |
| 988 ## - NOTA LOCAL 598 |
|---|
| Nota local 598 (boletines) |
Springer_Protocols_2018 |
| 700 1# - PUNTO DE ACCESO ADICIONAL--NOMBRE DE PERSONA |
|---|
| Nombre de persona |
Chen, Minjun |
| Término indicativo de función/relación |
editor literario |
| Código de función/relación |
edt |
| -- |
http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - PUNTO DE ACCESO ADICIONAL--NOMBRE DE PERSONA |
|---|
| Nombre de persona |
Will, Yvonne |
| Término indicativo de función/relación |
editor literario |
| Código de función/relación |
edt |
| -- |
http://id.loc.gov/vocabulary/relators/edt |
| 776 08 - ENTRADA/ENLACE A UN FORMATO FÍSICO ADICIONAL |
|---|
| Información de relación/Frase instructiva de referencia |
Printed edition: |
| Número Internacional Estándar del Libro |
9781493976768 |
| 776 08 - ENTRADA/ENLACE A UN FORMATO FÍSICO ADICIONAL |
|---|
| Información de relación/Frase instructiva de referencia |
Printed edition: |
| Número Internacional Estándar del Libro |
9781493976782 |
| 776 08 - ENTRADA/ENLACE A UN FORMATO FÍSICO ADICIONAL |
|---|
| Información de relación/Frase instructiva de referencia |
Printed edition: |
| Número Internacional Estándar del Libro |
9781493992560 |
| 856 40 - LOCALIZACIÓN Y ACCESO ELECTRÓNICOS |
|---|
| Identificador Uniforme del Recurso |
https://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-7677-5 |
| Nota pública |
(usuarios Universidad Europea de Valencia) |
| 942 ## - ELEMENTOS DE PUNTO DE ACCESO ADICIONAL (KOHA) |
|---|
| Fuente del sistema de clasificación o colocación |
Library of Congress Classification |
| Tipo de ítem Koha |
LIBRO-E NO PRÉSTAMO |