Intro -- Preface -- Acknowledgements -- Contents -- Chapter 1: The Liver -- Hepatic Blood Flow -- Liver Lymphatics -- Liver Histology -- Liver Organization -- Liver Function -- References -- Chapter 2: Approach tothePatient withLiver Disease -- Symptoms ofLiver Disease -- Jaundice -- Fatigue -- Pruritus -- Poor Appetite andWeight Loss -- Abdominal Pain -- Alterations intheSenses ofTaste andSmell -- Personality Changes andSleep Disturbances -- Dyspnea -- Bleeding -- Stool Characteristics -- Vision Disturbance -- Bone Pain andFractures -- Pain -- Hyperpigmentation -- Vascular Ulcers -- Chills andRigors -- Dark Urine -- Sexual Dysfunction andDisinterest -- Muscle Cramps -- Identification ofRisks forLiver Disease -- Recognizing Hepatic Manifestations ofComorbidities -- Past Medical andSurgical History -- Family History -- Review ofSystems -- The Physical Examination -- Fetor Hepaticus -- The Skin, Mucous Membranes, andNails -- Glands andLymph Nodes -- Cardiovascular System -- Respiratory System -- Abdomen -- Extremities -- Neuropsychiatric Alterations -- Investigation ofLiver Disease -- Liver Biopsy -- References -- Chapter 3: Primary Biliary Cholangitis -- Etiology -- Genetics -- Epigenetics -- Epidemiology -- Clinical Manifestations -- Natural History -- Associated Conditions -- Physical Exam -- Laboratory Exams -- Radiographic Studies -- Serology andImmunological Features -- Histology -- Cellular Immunology -- Treatment -- Treatment ofComplications ofPBC -- Pruritus -- Fatigue -- Sicca Symptoms -- Osteoporosis -- Complications Secondary toChronic Scratching -- Cholelithiasis -- Xanthomata andXanthelasmata -- Complications fromLiver Disease fromPBC -- Portal Hypertension -- Hepatocellular Carcinoma -- Hepatic Synthetic Dysfunction -- References -- Chapter 4: Autoimmune Hepatitis -- Autoimmune Hepatitis -- Etiology

Pathogenetics -- Genetics -- Epigenetics -- Clinical Manifestations -- Physical Examination -- Autoantibodies -- Histology -- Diagnostic Scores forAIH -- Overlap Syndromes -- Treatment ofAutoimmune Hepatitis -- Hepatocellular Carcinoma -- Autoimmune Hepatitis inChildren -- Liver Transplantation -- References -- Chapter 5: Primary Sclerosing Cholangitis -- Sclerosing Cholangitis -- Etiology -- Genetics -- Clinical Manifestations -- Differential Diagnosis -- Physical Examination -- Laboratory Findings -- Diagnosis -- Immunology -- Cellular Pathogenesis -- Dysbiosis -- Histology -- Epidemiology -- Natural History -- Liver Transplantation -- Cholangiocarcinoma -- Treatment -- Therapy ofComplications Unique toPSC -- Liver Transplantation -- PSC inChildren -- References -- Chapter 6: Chronic Hepatitis C -- Etiology -- Genetics -- Epidemiology -- Natural History -- Clinical Manifestations -- Physical Exam -- Differential Diagnosis -- Histology -- Extrahepatic Manifestations -- Diagnosis -- Treatment -- Treatment ofConditions Associated withChronic Hepatitis C -- Cryoglobulinemia -- Porphyria Cutanea Tarda -- Nephropathy -- Xerostomia andXerophthalmia -- Lichen Planus -- Liver Transplantation -- References -- Chapter 7: Chronic Hepatitis B -- Etiology ofChronic Hepatitis B: Hepatitis B Virus -- Genetics -- Epidemiology -- Clinical Manifestations -- Extrahepatic Manifestations -- Characteristics ofChronic Hepatitis B Virus Infection -- Laboratory Findings andSerology -- Differential Diagnosis -- Liver Histology -- Natural History ofChronic Hepatitis B -- Impact ofCoinfection withHIV, HCV, andDelta Hepatitis Viri ontheNatural History ofChronic Hepatitis B -- Delta Hepatitis -- Treatment ofChronic Hepatitis B -- Indications forTreatment ofHepatitis B -- Drugs fortheTreatment ofChronic Hepatitis B -- Treatment ofChronic Delta Hepatitis

Liver Transplantation inPatients withChronic Hepatitis B andChronic Delta Hepatitis -- Hepatocellular Carcinoma inChronic Hepatitis B -- References -- Chapter 8: Alcohol Induced Liver Disease -- Etiology -- Genetics -- Epidemiology -- Natural History ofAlcoholic Liver Disease -- Clinical Manifestations -- Associated Conditions -- Laboratory andRadiological Exams -- Histology -- Treatment -- Alcohol Withdrawal -- Delirium Tremens -- Treatment ofAlcoholic Hepatitis -- References -- Chapter 9: Nonalcoholic Fatty Liver Disease -- Epidemiology -- Etiology -- Genetics -- Clinical Manifestations -- Natural History -- Liver Histology -- Inflammation: ItsPotential Role inthePathogenesis ofNAFLD -- NAFLD Associated Diseases -- Lean Nonalcoholic Fatty Liver Disease -- Treatment -- Bariatric Surgery -- References -- Chapter 10: Alpha-1-Antitrypsin Deficiency -- Genetics -- Epidemiology -- Natural History -- Clinical Manifestations -- Laboratory Tests -- Histology -- Hepatocellular Carcinoma -- Associated Conditions -- Treatment -- Liver Transplantation -- References -- Chapter 11: Hemochromatosis -- Iron Homeostasis -- Hepcidin -- Iron Mediated Injury -- Genetics -- Epidemiology -- Natural History -- Clinical Manifestations -- Laboratory Tests -- Histology -- Treatment -- Liver Transplantation -- Treatment ofOther Genetic Iron Overload Conditions -- Potential Pharmacological Treatment ofHepcidin-Ferroportin Disease -- References -- Chapter 12: Wilson's Disease -- Etiology -- Copper Homeostasis -- Genetics ofWilson's Disease -- Epigenetics -- Epidemiology -- Natural History -- Clinical Manifestations -- Acute Liver Failure -- Liver Histology -- Laboratory Findings -- Diagnostic Investigations -- Imaging Studies -- Transient Elastography -- Screening inWilson's Disease -- Treatment -- Hepatocellular Carcinoma -- Liver Transplantation -- References

Chapter 13: Tumors oftheLiver -- Simple Hepatic Cysts -- Polycystic Liver Disease -- Hydadtic Cysts -- Liver Abscess -- Hepatic Hemangiomata -- Focal Nodular Hyperplasia -- Hepatocellular Adenomata -- Hepatocellular Carcinoma -- Fibrolamellar Carcinoma -- Intrahepatic Cholangiocarcinoma -- Hepatic Angiosarcoma -- Hepatic Epithelioid Hemangioendothelioma -- Hepatic Mucinous Cystic Neoplasm -- References -- Chapter 14: Drug Induced Liver Injury -- Etiology -- Risk Factors forDili -- Genetics -- Age -- Gender -- Race andEthnicity -- Alcohol -- Pregnancy -- Comorbidities -- Chronic Liver Disease -- Drug Dependent Risk Factors -- Drug Metabolism -- Lipophilicity -- Drug Interactions -- Mitochondrial Toxicity -- Inhibition ofHepatobiliary Transporters -- Epidemiology -- Approach toaPatient withSuspected Drug-Induced Liver Injury -- Clinical Manifestations -- Laboratory Exams -- Imaging Studies -- Liver Histology -- Natural History -- Associated Conditions -- Treatment -- Prevention ofDrug-Induced Liver Injury -- References -- Chapter 15: Complications ofLiver Disease -- Pruritus -- Therapies that Aim at theRemoval ofthePruritogenic Substances(s) fromtheBody -- Antibiotics -- Changes inNeurotransmission -- Opiate Antagonists -- Serotonin Antagonists -- Antidepressants -- Potential Regulation ofa24-Hour Rhythm ofScratching Behavior -- Drugs toTreat theLiver Disease -- Fatigue -- Portal Hypertension -- Ascites -- Hepatic Hydrothorax -- Hyponatremia -- Bacterial Infections -- Spontaneous Bacterial Peritonitis -- Renal Insufficiency -- Hepatorenal Syndrome -- Muscle Cramps -- Hepatic Encephalopathy -- Cardiomyopathy -- Hepatopulmonary Syndrome -- Portopulmonary Hypertension -- Fat Malabsorption -- Vitamin Deficiencies -- Gynecomastia -- Cholelithiasis -- Malnutrition -- References -- Index

Comprising chapter-length case studies of patients with varied liver pathologies, this work enriches the knowledge of trainees and practicing clinicians, and includes a wealth of biopsy photographs, epidemiological analysis, and tabulated experimental data