Optical-Based Detectors -- Surface Plasmon Resonance and Surface Plasmon Field-Enhanced Fluorescence Spectroscopy for Sensitive Detection of Tumor Markers -- Surface Plasmon Resonance Biosensor for Biomolecular Interaction Analysis Based on Spatial Modulation Phase Detection -- Array-Based Spectral SPR Biosensor: Analysis of Mumps Virus Infection -- Optical Biosensors Based on Photonic Crystal Surface Waves -- Surface Plasmon Resonance Biosensing -- Label-Free Detection with the Resonant Mirror Biosensor -- Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform -- Reflectometric Interference Spectroscopy -- Phase Sensitive Interferometry for Biosensing Applications -- Label-Free Serodiagnosis on a Grating Coupler -- Indirect Detectors -- CCD Camera Detection of HIV Infection -- Simple Luminescence Detector for Capillary Electrophoresis -- Optical System Design for Biosensors Based on CCD Detection -- A Simple Portable Electroluminescence Illumination-Based CCD Detector -- Fluoroimmunoassays Using the NRL Array Biosensor -- Biosensors Technologies: Acousto-Optic Tunable Filter-Based Hyperspectral and Polarization Imagers for Fluorescence and Spectroscopic Imaging -- Photodiode-Based Detection System for Biosensors -- Photodiode Array On-chip Biosensor for the Detection of E. coli O157:H7 Pathogenic Bacteria -- DNA Analysis with a Photo-Diode Array Sensor -- Miniaturized and Integrated Fluorescence Detectors for Microfluidic Capillary Electrophoresis Devices -- Photomultiplier Tubes in Biosensors -- Integrating Waveguide Biosensor -- Detection of Fluorescence Generated in Microfluidic Channel Using In-Fiber Grooves and In-Fiber Microchannel Sensors -- Multiplex Integrating Waveguide Sensor: Signalyte™-II -- CCD Based Fiber-Optic Spectrometer Detection.

Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide variety of biodetection applications, offering the advantages of increased speed and ease of use compared to traditional detection methods. In Biosensors and Biodetection: Methods and Protocols, leading experts describe the major technologies in the field in extensive technical detail, allowing readers both to understand the technology and to construct similar devices. Volume 1: Optical-Based Detectors delves into direct and indirect optical detectors, including methods involving surface plasmon resonance, interferometric sensors, CCD based detectors, and spectrometers, among many other cutting-edge technologies. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the subjects, lists of the necessary materials, step-by-step, readily reproducible protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Biosensors and Biodetection: Methods and Protocols is an ideal, user-friendly guide to this vital, versatile technology and a perfect tool for those who wish to further the field.