Cytogenetics -- Cytogenetics Analysis -- FISH Analysis -- Comparative Genomic Hybridization for the Analysis of Leukemias and Lymphomas -- Spectral Karyotyping (SKY) of Hematologic Malignancies -- Polymerase Chain Reaction -- Molecular Genetic Methods in Diagnosis and Treatment -- Detecting Monoclonal Immunoglobulin andT-Cell Receptor Gene Rearrangements in B- andT-Cell Malignancies by Polymerase Chain Reaction -- Quantifying Residual Leukemia by "Clone-Specific" Polymerase Chain Reaction -- NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction for Detecting the t(2;5) of Non-Hodgkin's Lymphoma -- Flow Cytometry -- Diagnostic Flow Cytometry in Hematologic Malignancies -- Flow Cytometric Analysis of Hematologic Neoplasia -- In Situ Hybridization in Flow Cytometry -- Quantitative Fluorescence Cytometry -- Special Histopathology Stains -- Methods in Leukocyte Cytochemistry -- Immunohistochemistry in Leukemias and Lymphomas -- Molecular Genetics and Cytokines -- Apoptosis -- Cytokine Receptors.

Recent advances in molecular biology are transforming the treatment of hematologic malignancies by providing powerful new tools useful in both diagnosis and the assessment of new therapies. In Hematologic Malignancies: Methods and Techniques, a panel of acknowledged experts review many of the key molecular methods used for the diagnosis and subsequent management of hematologic malignancies. These clinically relevant techniques range from routine test procedures to highly sophisticated methods currently offered only by specialized reference laboratories, and fall into five major groups: cytogenetics, polymerase chain reaction, flow cytometry, cytochemistry and immunochemistry, and apoptosis and cytokine receptors. Presented by investigators with extensive experience, and serving not only as a reference for seasoned research and clinical laboratory personnel, but also as a guide for the less experienced, each method contains sufficient detail to ensure its successful replication. Serving both clinical and experimental needs, Hematologic Malignancies: Methods and Techniques provides an array of powerful tools that will guide clinicians- especially hematologists, oncologists, and pathologists-to better diagnose and manage their patients with hematologic malignancies, and enable researchers to assess the anticancer effect of agents that impact cancer cells at the molecular level.