Introduction: Refining Physiologic-Based Individualized Management of Cardio-Renal Syndrome -- 1. A Historical Perspective on Evolving Concepts of Cardio-Renal Syndrome in Heart Failure -- 2. Hemodynamic Insights to Cardio-Renal Syndrome: A View Looking Back to See Forward -- Part 1. Insights from Pathophysiologic Mechanisms -- 3. Mechanisms of Cardio-Renal Syndrome: From Molecular Pathways to Novel Therapeutics -- 4. Pathophysiology of Cardio-Renal Syndrome: Autonomic Mechanisms -- 5. Insights on Diuretic Therapy from Clinical and Pharmacologic Perspectives -- Part 2: Case-Based Discussions -- 6. A patient with chronic kidney disease and heart failure with reduced ejection fraction -- 7. A patient with chronic kidney disease and heart failure with preserved ejection fraction -- 8. Heart Failure in a Patient with End-Stage Kidney Disease and Renal Replacement Therapy -- 9. Loop diuretic resistance in a patient with chronic heart failure -- 10. Worsening renal function in a patient with acute heart failure and volume overload -- 11. Loop diuretic resistance in a patient with acute heart failure -- 12: Diuretic therapy complicated by hyponatremia -- 13. A patient with abdominal congestion -- 14. Hepatorenal Dysfunction in a Patient with Advanced Heart Failure -- 15. Low output heart failure: the cold and wet patient -- 16. Cardio-Renal Syndrome in a Patient with Mechanical Circulatory Support -- 17. Patient with Severe Right Heart Failure -- 18. Refractory congestion - when to use ultrafiltration?

This comprehensive manual reviews the management of cardiorenal syndrome in heart failure. Chapters are structured in a practically applicable and easy-to-follow format with realistic case vignettes and key clinical management questions and answers, followed by a brief discussion of underlying pathophysiological mechanisms of a patient with cardiorenal syndrome. Building from this case, key questions are posed that are relevant to the clinical management and then potential evidence-based treatment strategies are proposed. Topics covered include loop diuretic resistance in acute and chronic heart failure, abdominal congestion, low output failure and potential diuretic complications due to hyponatremia. Cardiorenal Syndrome in Heart Failure thoroughly reviews cardiorenal syndrome from the perspective of both the cardiologist and nephrologist. Its case-based approach makes it an ideal resource for both practising and trainee cardiology and nephrology practitioners. .