Introduction: Overview of Current Molecular Diagnostic Testing on Cytology Samples -- The Cytology Specimen and Preparations: Advantages and Limitations -- Sample Acquisition and Test Requisition -- Pre-Analytic Workflow and Specimen Evaluation -- DNA-Based Sequencing Assays -- RNA-Based Assays -- FISH Testing of Cytology Specimens: Pre-Analytic, Analytic and Post-Analytic Considerations -- Molecular Cytopathology Correlations: Interpretation of Molecular Diagnostic Results -- Human Papillomavirus (HPV) Testing of Head and Neck Cancers -- Human Papillomavirus (HPV) Testing on Cervical Cytology Specimens -- Molecular Diagnostics in Lung Cytology -- Molecular Diagnostics in Thyroid Cytology -- Molecular Diagnostics in Breast Cytology -- Molecular Diagnostics in Salivary Gland Cytology -- Molecular Diagnostics in Pancreatic and Biliary Cytology -- Fluorescence In Situ Hybridization (FISH) Testing in Urinary Tract Cytology -- Molecular Diagnostics in Hematological Malignancies -- Molecular Diagnostics in Bone and Soft Tissue Tumors -- Molecular Diagnostics in Pediatric Cytopathology -- Molecular Cytopathology: Final Thoughts and Future Directions.

The main focus of this book is to provide an overview of the principles of molecular diagnostics in context of cytopathology specimens together with a basic understanding and working knowledge of the available technology, platforms, and clinical applications. The initial sections of the book summarize the pre-analytic aspects of molecular testing, including cytology specimen preparation and handling, specimen selection and evaluation, and workflow algorithms as well as the analytic considerations for a variety of nucleic acid and protein-based testing. The remaining section focuses on disease specific molecular testing for various organ-based applications. Molecular Diagnostics in Cytopathology: A Practical Handbook for the Practicing Pathologist serves as a useful resource for cytopathologists, surgical pathologists, molecular technologists, and all others dealing with the evolving field of molecular cytopathology. .