1 Epidemiology of sarcopenia and frailty in CKD -- 2 Molecular mechanism of muscle wasting in CKD -- 3 Protein Energy Wasting in Chronic Kidney Disease -- 4 Benefit and risk of exercise training in CKD patients -- 5 "Frailty in patients with pre-dialysis CKD; Toward successful aging of the elderly patients transitioning to dialysis in Japan" -- 6 Exercise interventions in dialysis patients -- 7 Exercise intervention for kidney transplant recipients: recent progress and remaining issues -- 8 Role of nutrition and rehabilitation in the prevention and management of sarcopenia and frailty -- 9 Nutritional interventions in elderly pre-dialysis patients -- 10 Nutritional interventions in dialysis patients.-11 Pharmacological intervention for sarcopenia in CKD -- 12 Oral Health Management for the Prevention of Sarcopenia and Frailty -- 13 Frailty and cognitive impairment in CKD -- 14 Polypharmacy and frailty in CKD -- 15 Anemia management and QOL and frailty in CKD.

This book highlights recent advances in our understanding of sarcopenia and frailty in CKD. The prevalence of sarcopenia and frailty increases substantially as CKD progresses, and experimental studies have demonstrated the pivotal role of accumulated uremic toxin in the development of muscle wasting. Further, sarcopenia and frailty are associated with falls, bone fractures, cognitive impairment, and poor survival prognoses, especially in elderly CKD patients. The syndromes are also related to the risk of end-stage kidney disease. This book provides readers with a deeper understanding of the prevention and management of sarcopenia and frailty in CKD patients to improve their renal and overall health, and suggests directions for future basic and clinical research.