What is translational research? -- The importance of heart failure in modern societies -- A main reason of heart failure: cardiomyocyte loss -- Cell death forms- mechanisms -- What is cardiac remodelling -- The fetal phenotyp -- The ischemia- reperfusion injury -- Cardiac hypertrophy -- Inflammation -- Stunning-hibernation -- Preconditioning- post conditioning -- Periconditioning; a universal phenomenon -- Cardiac cell resuscitation -- Cardiac regeneration -- Therapeutical considerations: Drugs -- Therapeutical considerations: Genetic -- Therapeutical considerations: Molecular, miRs -- Therapeutical considerations: Devices -- Clinical trials in myocardial preservation -- The systems biology approach -- Genetic basis in cardiac remodelling -- Conclusions -- future directions
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This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.