Historical Perspectives
Front Matter
Pages 1-1
Creating the Future
John R. Adler Jr.
Pages 3-4
CyberKnife Warfare in America: Battles at the Border Between Neurosurgery and Radiation Oncology
Cole A. Giller
Pages 5-27
Physics
Front Matter
Pages 29-29
The CyberKnife Robotic Radiosurgery System
Argyris Moutsatsos, Evangelos Pantelis
Pages 31-43
The Target Locating System for CyberKnife Neuroradiosurgery
Warren Kilby
Pages 45-57
Treatment Planning
Matthias Schlüter, Daniela Schmitt, Christoph Fürweger, Achim Schweikard, Alexander Schlaefer
Pages 59-73
Small Field Dosimetry
Evangelos Pantelis, Argyris Moutsatsos
Pages 75-87
Quality Control
Evangelos Pantelis, Argyris Moutsatsos
Pages 89-105
Imaging
Front Matter
Pages 107-107
Morphological Imaging
Eleftherios P. Pappas, Evangelos Pantelis
Pages 109-128
Functional Imaging
Argyris Moutsatsos, Evangelos Pantelis
Pages 129-139
Diffusion Tensor Imaging (DTI) Tractography
Enmin Wang
Pages 141-153
Metabolic Imaging
Andrea d’Amico
Pages 155-161
Radiobiology
Front Matter
Pages 163-163
Radiobiology of Radiosurgery and Hypofractionated Treatments
Antonio Pontoriero
Pages 165-184
Organs at Risk (OAR) Tolerance in Hypofractionated Radiosurgery
Alfredo Conti
Pages 185-197
Oncology
Front Matter
Pages 199-199
Brain Metastases Surgical Management: Diagnostic, Therapeutic and Strategic Considerations
Philippe Metellus
Pages 201-211
Brain Metastasis: The Experience of the Burdenko Institute of Neurosurgery
Elena R. Vetlova, Andrey V. Golanov, Sergey M. Banov, Natalia A. Antipina, Amayak A. Durgaryan, Elena N. Igoshina et al.
Pages 213-223
Multiple Brain Metastases
Frederic Dhermain
Pages 225-232
CyberKnife Neuroradiosurgery for Large Brain Metastases and Tumor Bed
Maximilian I. Ruge
Pages 233-239
Convexity and Parasagittal Meningiomas
Alfredo Conti
Pages 241-247
Skull Base Meningiomas
Giuseppe Minniti, Alfredo Conti, Antonio Pontoriero
Pages 249-261
High-Grade Meningiomas and Hemangiopericytomas
Güliz Acker
Pages 263-270
Perioptic Meningiomas
Laura Fariselli, Valentina Pinzi, Sara Morlino, Marcello Marchetti
Pages 271-275
Optic Nerve Sheath Meningiomas
Carolin Senger
Pages 277-282
Vestibular Schwannomas
Alexander Muacevic, Paul Windisch, Joerg-Christian Tonn, Christoph Fürweger, Berndt Wowra, Markus Kufeld et al.
Pages 283-292
Large Vestibular Schwannomas
Alfredo Conti
Pages 293-299
Pituitary Adenomas
Hiromitsu Iwata, Yuta Shibamoto
Pages 301-307
Craniopharyngiomas
Andrey V. Golanov, Alexander N. Savateev, Yury Y. Trunin, Natalia A. Antipina, Konstantin V. Nikitin, Alexander N. Konovalov
Pages 309-321
Malignant Gliomas
Franziska Loebel
Pages 323-328
Pilocytic Astrocytomas
Yury Y. Trunin, Andrey V. Golanov, Alexander N. Konovalov, Natalia A. Antipina, Konstantin V. Nikitin
Pages 329-336
Pineal Tumors
Eun Suk Park, Young Hyun Cho
Pages 337-354
Reirradiation of Skull Base Tumors
Sławomir Blamek
Pages 355-369
Chordoma and Chondrosarcoma
Steve Braunstein
Pages 371-376
Paragangliomas of the Head and Neck
Kaan Oysul, Sait Sirin
Pages 377-387
Paragangliomas: A Case Series from Burdenko Center of Neurosurgery
Svetlana V. Zolotova, Andrey V. Golanov, Natalia A. Antipina, Anastasia V. Barabanova, Konstantin V. Nikitin
Pages 389-398
Brainstem Tumors
Gokhan Ozyigit, Sezin Yuce Sari
Pages 399-410
Uveal Melanoma
David Roberge
Pages 411-418
Pediatric Radiosurgery
Valérie Bernier-Chastagner
Pages 419-422
Immunotherapy and Radiosurgery
Ravi Medikonda, Michael Lim
Pages 423-436
Spine
Front Matter
Pages 437-437
Spinal Metastases
Souvik Roy, Nitin Agarwal, Steven A. Burton, John C. Flickinger, Peter Gerszten
Pages 439-449
Re-irradiation of Spinal Metastases
Emma M. Dunne, Timothy K. Nguyen, Jay Detsky, Mitchell Liu, Simon S. Lo, Arjun Sahgal
Pages 451-464
Radiosurgery for Benign Spinal Tumors
Scott G. Soltys, Antonio Meola, Alex Chin, Erqi Pollom
Pages 465-472
Intradural Spinal Lesions
Kita Sallabanda, Morena Sallabanda, Peter Gerszten
Pages 473-480
Vascular Lesions
Front Matter
Pages 481-481
Cerebral Arteriovenous Malformations
Umberto Fornezza, Zeno Perini, Gianpaolo Zambon, Mariano Zanusso, Leopoldo S. Casentini
Pages 483-496
Vascular Lesions
Large Arteriovenous Malformations
Umberto Fornezza, Zeno Perini, Leopoldo S. Casentini, Gianpaolo Zambon, Mariano Zanusso
Pages 497-504
Cyberknife Radiosurgery for Cerebral Cavernous Malformations
François Nataf
Pages 505-515
Dural Arteriovenous Fistulas
Juhana Frösen, Antti Lindgren
Pages 517-530
Cavernous Sinus Hemangioma
Enmin Wang
Pages 531-540
Functional Disorders
Front Matter
Pages 541-541
Trigeminal Neuralgia
Pantaleo Romanelli, Alfredo Conti
Pages 543-556
Movement Disorders
Marcello Marchetti, Alfredo Conti, Angelo Franzini, Laura Fariselli
Pages 557-564
Image-Guided Robotic Radiosurgery for the Treatment of Drug-Refractory Epilepsy
Pantaleo Romanelli, Alfredo Conti
Pages 565-577
Behavioral/Psychiatric Disorders
Sait Sirin, Kaan Oysul
Pages 579-588

This book is a practical guide on image-guided robotic (CyberKnife®) radiosurgery of the brain and the spine. The volume introduces the radiosurgical community to the potential of image-guidance in the treatment of neurosurgical diseases including neuro-oncological, vascular and functional disorders. Principles of image-guided radiosurgery, including physics and radiobiology are considered. Each chapter provides a critical review of the literature and analyses of several aspects to offer an assessment of single and hypofractionated treatments. Based on the authors’ experience, tables or summaries presenting the treatment approaches and associated risks are included as well. Providing a practical guide to define the selection of dose, fractionation schemes, isodose line, margins, imaging, constraints to the structures at risk will support safe practice of neuroradiosurgery. This book aims to shed new light on the treatment of neoplastic and non-neoplastic diseases of the central nervous system using the CyberKnife® image-guided robotic radiosurgery system. It will be adopted by neurosurgery residents and neurosurgery consultants as well as residents in radiation oncology and radiation oncologists; medical physicists involved in radiosurgery procedures may also benefit from this book.