Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges
Henning Willers, Iris Eke
Pages 1-16
Translating Targeted Radiosensitizers into the Clinic
Deborah E. Citrin, Kevin A. Camphausen
Pages 17-33
Mapping the Radiogenome of Human Cancers
Priyanka Gopal, Jessica A. Castrillon, Mohamed E. Abazeed
Pages 35-61
Mechanisms and Markers of Clinical Radioresistance
Michael S. Binkley, Maximilian Diehn, Iris Eke, Henning Willers
Pages 63-96
Preclinical Strategies for Testing of Targeted Radiosensitizers
Steven H. Lin, Rui Ye, Yifan Wang
Pages 97-114
3D Radiation Biology for Identifying Radiosensitizers
Anne Vehlow, Sara Sofia Deville, Nils Cordes
Pages 115-135
Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments
Karolin Schneider, Nadja Ebert, Ina Kurth, Michael Baumann
Pages 137-159
Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
Warren Floyd, Hsuan-Cheng Kuo, Jonathon E. Himes, Rutulkumar Patel, David G. Kirsch
Pages 161-190
Targeting the DNA Damage Response for Radiosensitization
Matthew T. McMillan, Theodore S. Lawrence, Meredith A. Morgan
Pages 191-218
Targeting Tumor Metabolism to Overcome Radioresistance
Daniel Wahl, Michael Petronek, Rashmi Ramachandran, John Floberg, Bryan G. Allen, Julie K. Schwarz
Pages 219-263
Targeting Tumor Hypoxia
Michael Skwarski, Elizabeth Bowler, Joseph D. Wilson, Geoff S. Higgins, Ester M. Hammond
Pages 265-299
Normalizing the Tumor Microenvironment for Radiosensitization
John D. Martin, Rakesh K. Jain
Pages 301-338
Radiosensitizers in the Era of Immuno-Oncology
Jonathan E. Leeman, Jonathan D. Schoenfeld
Pages 339-360

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers.
Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.