Molecular Mechanism of Lynch Syndrome
Kazuo Tamura
Pages 1-20
Clinical Features of Lynch Syndrome
Kohji Tanakaya
Pages 21-32
Pathology of Lynch Syndrome-Associated Tumors
Harumi Saeki, Okio Hino
Pages 33-39
Immunohistochemistry for Mismatch Repair Proteins
Shigeki Sekine
Pages 41-52
Genetic Analysis for Lynch Syndrome
Izumi Miyabe, Keisuke Tanaka, Kiwamu Akagi
Pages 53-70
Lynch Syndrome-Associated Gynecological Malignancies
Wataru Yamagami, Daisuke Aoki
Pages 71-78
Lynch Syndrome-Associated Urological Malignancies
Hisashi Hasumi, Masahiro Yao
Pages 79-83
Screening for Lynch Syndrome
Tatsuro Yamaguchi
Pages 85-92
Surveillance Colonoscopy for Lynch Syndrome Affected Individuals
Takeshi Nakajima
Pages 93-102
Surgical Approach for Colorectal Cancer in Patients with Lynch Syndrome
Hideyuki Ishida, Keiichiro Ishibashi, Kensuke Kumamoto
Pages 103-115
Immunotherapy for Lynch Syndrome Patients
Takeshi Nagasaka
Pages 117-122
Chemoprevention for Lynch Syndrome-Associated Malignancies
Michihiro Mutoh, Takumi Narita, Hideki Ishikawa
Pages 123-132
International Collaboration for Lynch Syndrome
Nagahide Matsubara
Pages 133-143

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition.
Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease’s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome.
Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.