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Clinical and Experimental Xenotransplantation: Background
Front Matter
Pages 1-1
A Brief History of Clinical Cross-Species Organ Xenotransplantation
David K. C. Cooper
Pages 3-26
The Pathobiology of Pig-to-Primate Xeno.: A Historical Review
David K. C. Cooper, Mohamed B. Ezzelarab, Hidetaka Hara, Hayato Iwase, Whayoung Lee, Martin Wijkstrom et al.
Pages 27-63
Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?
Qi Li, Hidetaka Hara, Zhongqiang Zhang, Michael E. Breimer, Yi Wang, David K. C. Cooper
Pages 65-78
Sensitization to Human Leukocyte Antigens and Xenotransplantation
Guerard Byrne
Pages 79-87
Pig Kidney and Heart Xenotransplantation in Nonhuman Primates: The Present Position
Front Matter
Pages 89-89
Kidney Xenotransplantation in Nonhuman Primates
David K. C. Cooper, Hidetaka Hara, Hayato Iwase, Takayuki Yamamoto, Abhijit Jagdale, Douglas J. Anderson et al.
Pages 91-106
Cardiac Xenotransplantation in Nonhuman Primates
David K. C. Cooper
Pages 107-117
Organ-Source Pig Genetic Engineering and Regulation
Front Matter
Pages 119-119
Gene-edited Pigs for Xenotransplantation
Willard Eyestone, Kent Adams, Suyapa Ball, John Bianchi, Steve Butler, Amy Dandro et al.
Pages 121-140
Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Design and Pathogen Prevention
Karl Kraebber, Edward Gray
Pages 141-153
Antibody-Mediated Allotransplant Rejection: Lessons for Xenotransplantation
Front Matter
Pages 155-155
Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection
Stuart J. Knechtle, Jean Kwun, Brendon Lovasik, Alton B. Farris, A. Joseph Tector, Andrew B. Adams
Pages 157-164
Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejection
Robert A. Montgomery
Pages 165-175
Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejection
Stanley C. Jordan, Noriko Ammerman, Ashley Vo
Pages 177-189
Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newborn
Jeffrey L. Platt, Marilia Cascalho
Pages 191-201
Patient Evaluation and Selection for First Clinical Trials of Kidney or Heart Xenotransplantation
Front Matter
Pages 203-203
Defining an “Acceptable Risk Threshold”: Who Should Be the First Kidney Xenotransplant Recipient?
Jayme E. Locke
Pages 205-207
Selection of Patients for the Initial Clinical Trials of Kidney Xenotransplantation
David K. C. Cooper, Abhijit Jagdale, Roslynn B. Mannon, Vineeta Kumar, Robert Gaston, Michael J. Hanaway et al.
Pages 209-220
Selection of Patients for the Initial Clinical Trials of Cardiac Xenotransplantation
Richard N. Pierson III, Lars Burdorf, David A. D’Alessandro
Pages 221-232
Selection of Pediatric Patients for the Initial Clinical Trials of Cardiac Xenotransplantation
James K. Kirklin, David C. Cleveland
Pages 233-242
Infection in Xenotransplantation: Organ-Source Health and Patient Safety
Jay A. Fishman
Pages 243-252
Histocompatibility Testing for Xenotransplantation
Joseph M. Ladowski, Gregory R. Martens
Pages 253-263
Regulatory, Economic, and Social Aspects of Clinical Trials of Xenotransplantation
Front Matter
Pages 265-265
Xenotransplantation: The FDA Perspective
Winson W. Tang, Judith Arcidiacono
Pages 267-271
Xenotransplantation: A Payer’s Perspective
Jon Friedman
Pages 273-276
Public Perceptions Toward the Clinical Trials of Organ Xenotransplantation
Wayne Paris, Chace Mitchell, Zoie Werkheiser, Alan Lipps, David K. C. Cooper, Luz A. Padilla
Pages 277-285
Summation
Front Matter
Pages 287-287
What Did the Workshop Achieve?
Devin E. Eckhoff, Guerard Byrne
Pages 289-297

This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation.
The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation.
A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.