Prologue
Front Matter
Pages 1-1
Perspectives of the Danger/Injury Model in Immunology
Walter Gottlieb Land
Pages 3-9
A Select, Clinically Oriented Update of Topics Presented in “Damage-Associated Molecular Patterns in Human Diseases”; Volume 1: Injury-Induced Innate Immune Responses
Front Matter
Pages 11-11
Pattern Recognition Molecules
Walter Gottlieb Land
Pages 13-65
The Growing World of DAMPs
Walter Gottlieb Land
Pages 67-116
The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death
Walter Gottlieb Land
Pages 117-150
DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation
Walter Gottlieb Land
Pages 151-209
DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis
Walter Gottlieb Land
Pages 211-257
DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases
Front Matter
Pages 259-259
DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics
Walter Gottlieb Land
Pages 261-278
DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma
Walter Gottlieb Land
Pages 279-335
Solid Organ Injury
Walter Gottlieb Land
Pages 337-430
Atherosclerosis
Walter Gottlieb Land
Pages 431-533
Cerebro-Cardiovascular Diseases
Walter Gottlieb Land
Pages 535-623
Epilogue
Front Matter
Pages 625-625
The “DAMPome” as a Key Player in the Pathogenesis of Human Diseases
Walter Gottlieb Land
Pages 627-629

This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases.
Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities.
Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work.
The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists.

Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses