From NMR to Clinical Breast MRI
Francesco Sardanelli, Franca Podo
Pages 1-9
The Mantra about Low Specificity of Breast MRI
Pascal A. T. Baltzer, Francesco Sardanelli
Pages 11-21
Hereditary Breast Cancer: BRCA and Other Susceptibility Genes
Jacopo Azzollini, Laura Fontana, Siranoush Manoukian
Pages 23-41
MRI Protocols for Breast Cancer Screening
Ritse M. Mann, Suzan Vreemann
Pages 43-61
Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention
Francesco Sardanelli, Simone Schiaffino, Andrea Cozzi, Luca A. Carbonaro
Pages 63-82
Applying the MRI BI-RADS in a High-Risk Population
Paola Clauser, Chiara Zuiani
Pages 83-95
CAD and Machine Learning for Breast MRI
Anne L. Martel
Pages 97-111
Radiogenomics and Phenotype Presentation of Breast Cancer with a Special Focus on High-Risk Women
Katja Pinker, Anke Meyer-Baese, Elizabeth Morris
Pages 113-130
Primary Studies on Breast MRI Screening of High-Risk Women
Francesco Sardanelli, Franca Podo
Pages 131-151
Genetic/Familial High-Risk Screening: MRI Alone?
Maria A. Marino, Paola Clauser, Thomas H. Helbich
Pages 153-166
Systematic Reviews, Meta-Analyses, and Cost-Effective Analyses on Breast MRI Screening of High-Risk Women
Francesco Sardanelli, Giovanni Di Leo, Nehmat Houssami
Pages 167-187
Radioprotection Issues for Women with Hereditary Predisposition for Breast Cancer
Catherine Colin, Nicolas Foray, Michel Bourguignon
Pages 189-200
Impact of MRI Screening on High-Risk Patient Outcome
Franca Podo, Ellen Warner, Filippo Santoro, Francesco Sardanelli
Pages 201-221
The Special Case of Previous Chest Radiation Therapy
Rubina M. Trimboli, Giovanna Mariscotti
Pages 223-234
Electronic Data Capture Systems for Breast Cancer Research
Giovanni Di Leo, Daniela Sacchetto, Filippo Santoro
Pages 235-250
Guidelines and Recommendations on High-Risk Breast Cancer Screening All Over the World: Agreements and Differences
Ayla Selamoglu, Fiona J. Gilbert
Pages 251-267
A Soft Option for Primary Prevention: Drugs and Agents
Bernardo Bonanni, Massimiliano Cazzaniga, Matteo Lazzeroni
Pages 269-278
Surgical Options for Primary Prevention: Prophylactic Mastectomy and Oophorectomy
James O. Murphy, Virgilio Sacchini
Pages 279-291
Psychological Aspects of High Risk of Breast Cancer
Nadia Crotti, Valentina Broglia
Pages 293-307
Calculating, Using and Improving Individual Breast Cancer Risk Estimates
Adam R. Brentnall, Stephen W. Duffy
Pages 309-324
MRI for Screening Women with a Personal History of Breast Cancer
Manisha Bahl, Giovanni Di Leo, Constance D. Lehman
Pages 325-341
Breast MRI Screening for the Intermediate Risk: An Open Issue
Sylvia H. Heywang-Köbrunner, Astrid Hacker
Pages 343-354
Hypotheses for the Future
Francesco Sardanelli, Franca Podo
Pages 355-369
Back Matter
Pages 371-376

This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomics of breast cancer in high-risk women, computer-aided detection/diagnosis and machine learning systems applied to breast MRI, and psycho-oncology issues. Alternatives to breast MRI screening such as pharmaco-prevention and prophylactic mastectomy are also discussed, taking into account the public debate on the “Angelina Jolie” effect. The high breast cancer risk model is proposed as a paradigm for personalized medicine. This book will be of interest to radiologists, surgeons, oncologists and to all professionals devoted to female healthcare.