Intro -- Foreword -- Preface -- Contents -- Contributors -- Part I: Sedation and Analgesia for the Critically Ill Child -- Chapter 1: Introduction to Sedation and Analgesia -- Brief History of Pediatric Sedation and Analgesia -- Goal of Sedation and Analgesia in the Critically Ill Child -- Physiology of Pain -- Complexities of Sedation and Analgesia in the Critically Ill Child -- References -- Chapter 2: Safety and Monitoring During Pediatric ICU Sedation -- Assessment Tools -- Pain Assessment -- Self-Report Tools and Surrogate Reporting -- Observational Tools

Agitation and Sedation Assessment -- Objective Monitoring Tools -- Processed EEG -- Conventional EEG -- Conclusions -- References -- Chapter 3: Analgesic Use in the Pediatric Intensive Care Unit -- Specific Agents -- References -- Chapter 4: Regional Analgesia and Its Role in the PICU -- Introduction -- History -- Safety and Risks of Regional Anesthesia -- Benefits of Regional Anesthesia -- Some Common Blocks -- Central Neuraxial Blocks -- Upper Extremity Blocks -- Truncal Blocks -- Lower Extremity Blocks -- Conclusion -- References -- Part II: Sedative Agents

Chapter 5: Sedative Agents (Benzodiazepines) -- Overview of Benzodiazepines and Mechanism of Action -- Pharmacokinetic and Pharmacodynamic Considerations -- Adverse Reactions, Drug-Drug Interactions, and Monitoring Parameters -- Benzodiazepine and Opioids -- Breastfeeding/Pregnancy Considerations -- Pregnancy Considerations -- Breastfeeding Considerations -- In Summary -- References -- Chapter 6: Alpha-Agonists in Pediatric Critical Care -- Introduction -- Pharmacology -- Clinical Applications -- Conclusion -- References -- Chapter 7: Barbiturates in the Pediatric ICU -- Introduction

Pharmacology -- Clinical Applications -- References -- Part III: Anesthetic Agents -- Chapter 8: Sedation and Analgesia for the Critically Ill Child: Ketamine -- Introduction -- Pharmacokinetics and Pharmacodynamics -- Mechanism of Action -- Dosing -- Uses of Ketamine in the Pediatric Intensive Care Unit -- Ketamine for Sedation -- Ketamine for Acute Pain -- Ketamine for Chronic Pain -- Ketamine Side Effects -- Conclusion -- References -- Chapter 9: Propofol for Sedation of the Critically Ill Child -- Introduction -- Pharmacology -- Mechanism of Action -- Pharmacokinetics -- Pharmacodynamics

Clinical Considerations for Use -- Indications for Short-Term, Deep Sedation -- Propofol "Drug Washout" -- The Impact of Propofol on Sleep and Delirium in ICU Patients -- Palliative Sedation -- Propofol-Related Infusion Syndrome (PRIS) -- Pathophysiology -- Prevention and Treatment -- Consideration in Special Populations -- Mitochondrial and Metabolic Disorders -- Conclusions -- Bibliography -- Chapter 10: Inhalational Agents: What Volatile Inhalational Agents Are and How to Use Them in the ICU Setting -- Introduction -- Principles of Inhalational Agents -- Minimum Alveolar Concentration