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3 Treatments: Anti-Influenza Agents and Antibiotics

Intro -- Preface -- Contents -- Part I: Introduction -- Chapter 1: Global Strategy for Influenza Viral Infection: What Is the Latest Information from WHO? -- 1 Introduction -- 2 International Health Regulations (IHR), 2005 -- 3 Swine-Origin H1N1 Pandemic Influenza in 2009 -- 4 Pandemic Influenza Preparedness (PIP) Framework -- 5 Emergency Risk Management for Health Approach -- 6 Core Public Health Capacity Strengthening -- 7 The Global Influenza Strategy for 2019-2030 -- 8 Conclusion -- References -- Part II: Definition, Epidemiology, and Pathogenesis

Chapter 2: Epidemiology of Influenza with a Description of Recent Trends in Japan: What Are the Key Epidemiologic Features of Seasonal Influenza? -- 1 Introduction -- 2 Overview of Influenza -- 3 Influenza Pandemics and the Zoonotic Link -- 4 Epidemiology: Time, Place, Person, and Virus -- 4.1 Seasonal Influenza: Global Burden and Surveillance -- 4.2 Seasonal Influenza Surveillance in Japan -- 4.3 Recent Epidemiologic Features of Seasonal Influenza in Japan -- 5 Conclusion -- References -- Chapter 3: Transmission of Influenza Virus in the Home: How Are They Transmitted in the Home?

1 Introduction -- 2 Subjects and Methods -- 2.1 Data Collection -- 2.2 Definition of Household Transmission -- 2.3 Data Analysis -- 2.3.1 Secondary Infection Rates with Stratification of Household Members According to Generation/Age -- 2.3.2 Influence of Viral Load Kinetics on Household Transmission -- 3 Analysis Results -- 3.1 Household Transmission Rate -- 3.2 Household Secondary Infection Rate -- 3.3 Effect of NAIs on Daily Secondary Infection Rate -- 4 Discussion -- 5 Conclusions -- References

Chapter 4: Cellular and Biochemical Pathogenic Processes in Severe Influenza Virus Infection: How Does Cytokine Storm Play a Role? -- 1 Introduction -- 2 Cellular Trypsin-Type Viral Envelope-Processing Proteases, Essential Factors for Initial Viral Infection and Viral Multi-Replication Cycle -- 3 Interconnection Between "Influenza Virus-Cytokine-Trypsin" Cycle and "Metabolic Disorder-Cytokine" Cycle Exacerbates ATP Crisis and MOF in the Advanced Stage of IAV Infection -- 4 Conclusion -- References

Chapter 5: Pathology of Severe Influenza Virus Pneumonia: What Is the Importance of Alveolar Mouths? -- 1 Introduction -- 2 Location and Structure of Alveolar Mouths (AMs) (Fig. 5.1) -- 3 AMs and Organizing Pneumonia (OP) (Fig. 5.2) -- 4 AMs and Hyaline Membranes (HMs) (Fig. 5.3) -- 5 Diffuse Alveolar Damage (DAD) -- 6 Conclusions -- References -- Chapter 6: Pathology, Diagnosis, and Treatment of Influenza Infections/Pneumonia: What Are the Mechanisms of Secondary Bacterial Pneumonia? -- 1 Introduction -- 2 Pathology and Classification of Influenza-Related Pneumonia