Digital transformation will affect every company or organization sooner or later, regardless of the industry, country, or type of organization. In recent years, this impact has become disruptive, and there is an increasing need for companies to innovate their business models while using various emerging technologies. The key goals of this book are twofold. The first goal is to provide a comprehensive overview of the state of digital transformation in business using various bibliometric indicators, while the second goal is to propose a synthesis of the potential directions and opportunities for future research agenda related to this field of research. The bibliometric analysis of the current state of knowledge published in the field of digital transformation in business over the last 20 years reveals the existence of four major thematic clusters: (1) the digital transformation process, (2) digital technologies, (3) the digital economy, and (4) digital disruption. Based on the content analysis of the most important articles that belonged to each cluster of topics, the book outlines several directions for future research. This makes it a useful resource for researchers interested in the field of digital transformation in business.