This handbook provides a summary of more than two decades of international research on one of the leading theoretical models of work stress research; effort-reward imbalance. Consisting of 3 parts and 8 sub-parts, this essential reference work deals with theory and methods, review of research evidence on health effects, new findings from Asia, Australia, and Latin America, and model extensions and interventions. This book has a selective theoretical focus, and the large majority of chapters is restricted to the meso-level of organizational research. With a combination of research evidence derived from macro-, meso- and micro-level investigations, the inclusion of a broad spectrum of material and psychosocial occupational stressors, and with its unique focus on socioeconomic determinants this handbook offers a valuable source of information to a broad audience interested in occupational health science.