Sterols from the Post-Lanosterol Part of Cholesterol Synthesis: Novel Signaling Players
Cene Skubic, Damjana Rozman
Pages 1-22
Genetic Variability in Cholesterol Metabolism
Caitlin J. Smith, John M. Dagle, Kelli K. Ryckman
Pages 23-40
Side-Chain Oxidized Oxysterols in Health and Disease
Ingemar Björkhem, Ulf Diczfalusy
Pages 41-79
Bile Acids and TGR5 (Gpbar1) Signaling
Verena Keitel, Christoph G. W. Gertzen, Sven Schäfer, Caroline Klindt, Christina Wöhler, Kathleen Deutschmann et al.
Pages 81-100
Bile Acids as Regulatory Signalling Molecules
Madlen Matz-Soja
Pages 101-116
Oxysterols and Bile Acid Act as Signaling Molecules That Regulate Cholesterol Homeostasis: Nuclear Receptors LXR, FXR, and Fibroblast Growth Factor 15/19
Klementina Fon Tacer
Pages 117-143
Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids
F. Peter Guengerich, Francis K. Yoshimoto
Pages 145-171

This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.