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020 _a9783319434865
024 7 _a10.1007/978-3-319-43486-5
_2doi
040 _aES-MaUEC
_bspa
_dES-VaUE
050 4 _aRC271 .I46
_b2018 EB
245 0 0 _aImmunotherapy for Pediatric Malignancies
_cedited by Juliet C. Gray, Aurélien Marabelle.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _a1 recurso en línea (IX, 297 páginas 29 ilustraciones, 27 ilustraciones a color)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aMedicine (Springer-11650)
505 0 _aIntroduction to Pediatric Cancer Immunotherapy -- Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy -- Allogeneic stem cell transplantation -- Overview of monoclonal antibody therapies -- Monoclonal Antibodies Targeting Hematological Malignancies -- Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours -- Monoclonal antibodies targeting the immune system -- Adoptive T Cell Therapies for Children’s Cancers -- NK Cell and NKT Cell Immunotherapy -- Cancer Vaccines in Pediatrics -- Immune Adjuvants and Cytokine Therapies -- Immune biomarkers in pediatric malignancies -- Future perspectives.
520 3 _aThis book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy. Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
988 _aEBSPRINGER_2018
650 7 _aOncología
_9139207
_2embne
650 7 _aCáncer en niños
_2embne
_9157453
650 7 _aImmunoterapia
_2embne
700 1 _aGray, Juliet C.
_eeditor literario
_0http://viaf.org/viaf/16151963695500312714
700 1 _aMarabelle, Aurélien.
_eeditor literario
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_0http://viaf.org/viaf/148105729
_9106996
776 0 8 _iEdición impresa:
_z9783319434841
776 0 8 _iEdición impresa:
_z9783319434858
776 0 8 _iEdición impresa:
_z9783319828374
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-43486-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_feng
_ggw
_h0