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008			180116s2018 si a s |||| 0|eng d
020			_a9789811076916
024	7		_a10.1007/978-981-10-7691-6 _2doi
040			_bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS403 .T36 _b2018 EB
100	1		_aTamamura, Hirokazu _eautor _4http://id.loc.gov/vocabulary/relators/aut _0http://id.loc.gov/authorities/names/n2018188058 _9669871
245	1	0	_aMid-size Drugs Based on Peptides and Peptidomimetics : _bA New Drug Category _cby Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi.
264		1	_aSingapore _bSpringer Singapore : _bImprint: Springer _c2018.
300			_a1 recurso en línea ( XVII, 100 páginas, 40 ilustraciones, 32 ilustraciones a color)
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490	0		_aSpringerBriefs in Pharmaceutical Science & Drug Development _x1864-8118
490	0		_aMedicine (Springer-11650)
505	0		_a1. Introduction of Mid-Size Drugs and Peptidomimetics -- 2. Chloroalkene Dipeptide Isosteres as Peptidomimetics -- 3. Conformational-restricted Cyclic Peptides -- 4. Peptidomimetics that Mimic Secondary Structures of Peptides -- 5.Peptidomimetics that Mimic Tertiary Structures of Peptides -- 6. Conjugated Compounds Involving Peptides -- 7. Summary and Future Perspectives of Researches on Mid-Size Drugs.
520			_aThis brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.
700	1		_aKobayakawa, Takuya _eautor _9669872
700	1		_aOhashi, Nami _eautor _9669873
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iPrinted edition: _z9789811076909
776	0	8	_iPrinted edition: _z9789811076923
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-7691-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0