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020 _a9783319640969
024 7 _a10.1007/978-3-319-64096-9
_2doi
040 _bspa
_dES-VaUE
050 4 _aRB1
_b.P74 2018EB
245 1 0 _aPrecision Molecular Pathology of Prostate Cancer
_cedited by Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _aXIV, 570 p. 50 illus., 48 illus. in color.
_bonline resource.
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
490 1 _aMolecular Pathology Library,
_x1935-987X
490 _aMedicine (Springer-11650)
505 0 _aPart I. General principles -- Approach to patient -- Etiology -- Precursor and pre-invasive lesions of prostate cancer -- Prostatic adenocarcinoma: morphologic spectrum, Gleason scoring, etc -- Genetic susceptibility -- DNA damage repair, BRCA mutations, DNA adducts, SNPs -- Racial differences -- Cancer stem cells Part II. Molecular signatures of primary prostate cancer -- SNPs -- Copy number variation/chromosomal aberration (PTEN deletion, etc.) -- Gene fusions (TMPRSS2:ERG, etc.) -- Gene expression arrays -- Next generation sequencing (point mutations, indels, etc.) -- Epigenetic changes (chromatin remodeling, etc.) -- Proteomics -- Metabolomics -- miRNA and lncRNA Part III. Molecular signatures of advanced prostate cancer -- Lymph node metastasis -- Bone metastasis a -- RANKL, Src kinases, endothelins, bisphosphonates -- Visceral metastasis a -- Role of extracellular matrix, angiogenesis, epithelial-mesenchymal transition (EMT), inflammation -- Castration resistant prostate cancer (CRPC) -- Neuroendocrine prostate cancer (NEPC) Part IV. Key molecular pathways in prostate cancer development and progression -- Androgen receptor in carcinogenesis -- Androgen receptor in progression (CRPC) -- PI3K/Akt/mTOR/PTEN and ERK/MAPK pathways -- Cell cycle regulators (p53, etc.) -- DNA damage repair --         Tyrosine kinase signaling (EGFR, VEGFR, PDGFR, FGFR, IGFR, etc.) -- Cytoskeletal function (microtubules and taxane therapy) Part V. Precision medicine approach: Diagnosis, treatment, prognosis -- Molecular diagnosis -- Molecular imaging -- Molecular prognostic markers/tests -- Molecular targeted therapies -- Towards molecular classification of prostate cancer.
520 _aThis volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches.  The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease.  The book consists of five sections which provide insight about the following:  (1) General principles;  (2) Molecular signatures of primary prostate cancer;  (3) Molecular signatures of advanced prostate cancer;  (4) Key molecular pathways in prostate cancer development and progression;  (5) Precision medicine approach: Diagnosis, treatment, prognosis.   Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.  .
653 0 _aPathology.
653 0 _aOncology  .
653 0 _aUrology.
700 1 _aRobinson, Brian D.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMosquera, Juan Miguel.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRo, Jae Y.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aDivatia, Mukul.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_9106996
776 0 8 _iPrinted edition:
_z9783319640945
776 0 8 _iPrinted edition:
_z9783319640952
776 0 8 _iPrinted edition:
_z9783319877211
830 0 _aMolecular Pathology Library,
_x1935-987X
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64096-9
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db