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020 _a9789811072963
024 7 _a10.1007/978-981-10-7296-3
_2doi
040 _aES-MaUEC
_bspa
_dES-MaUEC
050 4 _aQP517
_b.C45 2018 EB
245 0 0 _aRegulation of Signal Transduction in Human Cell Research
_cedited by Nariyoshi Shinomiya, Hiroaki Kataoka, Qian Xie.
264 1 _aSingapore
_bSpringer Singapore :
_bImprint: Springer
_c2018.
300 _a1 recurso en línea (VIII, 218 páginas 49 ilustraciones, 41 ilustraciones a color)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aCurrent Human Cell Research and Applications,
_x2522-073X
490 0 _aMedicine (Springer-11650)
520 3 _aThis volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
650 7 _9138639
_aBioquímica
_2embne
650 7 _aTransducción de la señal celular
_2embne
_9163198
700 1 _aShinomiya, Nariyoshi.
_eeditor literario
_0http://id.loc.gov/authorities/names/n2018187558
_0http://viaf.org/viaf/3153833239464332916
700 1 _aKataoka, Hiroaki.
_eeditor literario
_0http://id.loc.gov/authorities/names/n2018187557
_0http://viaf.org/viaf/5153833239064332907
700 1 _aXie, Qian.
_eeditor literario
_0http://id.loc.gov/authorities/names/n83126009
_0http://viaf.org/viaf/119042516
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_0http://viaf.org/viaf/148105729
_9106996
776 0 8 _iEdición impresa:
_z9789811072956
776 0 8 _iEdición impresa:
_z9789811072970
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-7296-3
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db