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020 _a9813360135
024 7 _a10.1007/978-981-33-6013-6
_2doi
040 _bspa
_dES-VaUE
050 _aRC280
_b.I86 2021 EB
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
072 7 _aMJCL
_2thema
082 0 4 _a616.994
_223
245 1 0 _aMolecular Diagnosis and Targeting for Gynecologic Malignancy
_cedited by Seiji Isonishi, Yoshihiro Kikuchi
250 _a1st ed. 2021
264 1 _aCham
_bSpringer Nature
_c2021
300 _a1 online resource (VIII, 165 p. 26 illus., 24 illus. in color.)
336 _atext
_btxt [
_2rdacontent]
337 _acomputer
_bc [
_2rdamedia]
338 _aonline resource
_bcr [
_2rdacarrier]
490 1 _aCurrent Human Cell Research and Applications
_x2522-073X
505 0 _a1 Cancer Stem Cells in gynecologic cancer -- 2 Patient-derived xenograft models in gynaecological malignancies -- 3 Cancer genomic profiling of gynecological malignancies by Todai OncoPanel, a twin DNA and RNA panel -- 4 Investigating the molecular carcinogenesis of ovarian high-grade serous cancer -- 5 The role of G protein-coupled receptor signaling in gynecologic malignancy -- 6 Tailor-made therapy according genetic alteration in epithelial ovarian cancers -- 7 Signaling and drug resistance -- 8 Molecular analysis in endometrial carcinoma -- 9 Molecular Landscape in Ovarian Clear Cell Carcinoma -- 10 Molecular pathology and clinicopathological significance of endometrial carcinoma -- 11 Novel approach for therapeutics of cervical cancer based on HPV-associated carcinogenesis at the cervix -- 12 Hereditary gynecological malignancy and molecular features
520 _aThis book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases
650 0 _aOncology��
650 0 _aGynecology�
650 0 _aCancer research
650 0 _aCell biology
650 1 4 _aOncology.
650 2 4 _aGynecology.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
700 1 _aIsonishi, Seiji.,
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKikuchi, Yoshihiro.,
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 _z981-336-012-7
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-33-6013-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db