000 03846nam a22004215i 4500
999 _c11017
_d11017
001 11017
003 DE-He213
005 20210629040335.0
006 a||||fo|||| 00| 0
007 cr nn 008mamaa
008 180425s2018 gw | s |||| 0|eng d
020 _a9783319642574
024 7 _a10.1007/978-3-319-64257-4
_2doi
040 _bspa
_dES-VaUE
050 4 _aRC643
_b.A28 2018 EB
245 1 0 _aAcute Promyelocytic Leukemia :
_bA Clinical Guide
_cedited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _a1 recurso en línea ( XII, 274 páginas 39 ilustraciones, 29 ilustraciones a color)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
490 _aMedicine (Springer-11650)
505 0 _aHistory of APL -- Molecular Targets of Treatment in APL -- The Leukemic Stem Cell -- The Molecular Genetics of APL -- APL Coagulopathy -- Early Death in APL -- Prognostic Factors in APL -- First-line therapy for APL: Chemotherapy-based approach -- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach -- Cure of APL without Chemotherapy -- Minimal Residual Disease in APL -- Treatment of refractory and relapsed APL -- Hematopoietic Stem Cell Transplantation in APL -- APL in Children -- Management of APL in the Elderly -- Special Situations in APL -- APL in Developing Countries: A Chemotherapy-Based Approach -- APL in Developing Countries: ATO based Approach -- Therapy-Related APL -- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes -- Management of Treatment-Related Complications in APL.
520 _aThis book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
988 _aEBSPRINGER_MEDICINA_FEB2019
650 7 _aLeucemia
_9140673
700 1 _aAbla, Oussama
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/n2009182367
700 1 _aLo Coco, Francesco
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/n2018186600
700 1 _aSanz, Miguel A
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_9106996
776 0 8 _iPrinted edition:
_z9783319642567
776 0 8 _iPrinted edition:
_z9783319642581
776 0 8 _iPrinted edition:
_z9783030097134
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64257-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_feng
_ggw
_h0