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007			cr nn 008mamaa
008			180801s2018 gw | s |||| 0|eng d
020			_a9783319914428
024	7		_a10.1007/978-3-319-91442-8 _2doi
040			_aES-MaUEC _bspa _dES-MaUEC
050		4	_aRC268.4 _b.S63 2018 EB
245	0	0	_aSmall Molecules in Oncology _cedited by Uwe M. Martens.
250			_a3rd edition
264		1	_aCham, Switzerland _bSpringer _c2018
300			_a1 recurso en línea (VIII, 276 páginas 34 ilustraciones, 19 ilustraciones a color)
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aRecent Results in Cancer Research, _x0080-0015 ; _v211
490	0		_aMedicine (Springer-11650)
505	0		_aErlotinib -- Lapatinib -- Sorafenib -- Regorafenib -- Crizotinib -- Cabozantinib -- Vemurafenib -- Trametinib -- Everolimus -- Vismodegib -- Larotrectinib -- Palbociclib -- Taselisib -- Cobimetinib -- Lenvatinib -- Afatinib -- Olaparib -- Gefitinib -- Ceritinib. .
520	3		_aThis book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology. .
988			_aEBSPRINGER_2018
650		7	_aOncología _9139207 _2embne
650		7	_aCáncer _xAspectos genéticos _2embne _9273952
700	1		_aMartens, Uwe M. _eeditor literario _0http://id.loc.gov/authorities/names/nb2009032421 _0http://viaf.org/viaf/25758710 _988893
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783319914411
776	0	8	_iEdición impresa: _z9783319914435
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-91442-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0