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008			180802s2018 gw | s |||| 0|eng d
020			_a9783319789576
024	7		_a10.1007/978-3-319-78957-6 _2doi
040			_aES-MaUEC _bspa _dES-VaUE
050		4	_aRB155.8 _b.G46 2018 EB
245	1	0	_aGene Therapy in Reconstructive and Regenerative Surgery _cedited by Giorgio Giatsidis.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2018.
300			_a1 recurso en línea ( VII, 113 páginas 8 ilustraciones, 7 ilustraciones a color)
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490			_aMedicine (Springer-11650)
505	0		_aPrinciples of Gene Therapy in Reconstructive and Regenerative Surgery -- Gene Therapy in Skin and Wound Healing -- Gene Therapy in Pathologic Scars -- Gene Therapy in Skeletal Muscle Repair and Regeneration -- Gene Therapy in Cartilage Repair and Regeneration -- Gene Therapy in Tendon Repair and Regeneration -- Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery -- Developing a Gene Therapy Clinical Trial: Tips and Tricks -- Future Directions in Reconstructive and Regenerative Surgery.
520			_aThis book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
988			_aEBSPRINGER_MEDICINA_FEB2019
650		7	_aTerapia genética _2embne _9150702
700	1		_aGiatsidis, Giorgio _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _9106996
776	0	8	_iPrinted edition: _z9783319789569
776	0	8	_iPrinted edition: _z9783319789583
776	0	8	_iPrinted edition: _z9783030076894
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-78957-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0