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020 _a9783319952345
024 7 _a10.1007/978-3-319-95234-5
_2doi
040 _bspa
_dES-VaUE
050 4 _aRC268.4
_b.D54 2018 EB
245 1 0 _aDiffuse Gastric Cancer
_cedited by Tiago Biachi de Castria, Rodrigo Santa Cruz Guindalini.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _aX, 81 p. 9 illus., 6 illus. in color.
_bonline resource
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
490 _aMedicine (Springer-11650)
505 0 _a1. Introduction -- 2. Epidemiology -- 3. The Role of Endoscopy -- 4. Pathology and Molecular Biology -- 5. Genetic Predisposition and Hereditary Syndromes -- 6. The Role of Surgery -- 7. The Role of Radiotherapy -- 8. The Role of Chemotherapy.
520 _aWe live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
653 0 _aOncology  .
653 0 _aGastroenterology.
653 0 _aHuman genetics.
700 1 _ade Castria, Tiago Biachi.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGuindalini, Rodrigo Santa Cruz.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_9106996
776 0 8 _iPrinted edition:
_z9783319952338
776 0 8 _iPrinted edition:
_z9783319952352
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-95234-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_feng
_ggw
_h0