000			02907nam a22004095i 4500
999			_c11743 _d11743
001			11743
003			DE-He213
005			20210727040328.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			180926s2018 gw | s |||| 0|eng d
020			_a9783319945712
024	7		_a10.1007/978-3-319-94571-2 _2doi
040			_bspa _dES-VaUE
050		4	_aRC799 _b.A43 2018 EB
245	1	0	_aAlagille Syndrome : _bPathogenesis and Clinical Management _cedited by Binita M. Kamath, Kathleen M. Loomes.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2018.
300			_aXIV, 198 p. 41 illus., 31 illus. in color. _bonline resource
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF _2rda
490			_aMedicine (Springer-11650)
505	0		_aThe Alagille Syndrome: Overview and Introduction -- Bile Duct Development and the Notch Signaling Pathway -- Genetics of Alagille Syndrome -- Liver Disease in Alagille Syndrome -- Transplant Considerations in Alagille Syndrome -- Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome -- Vascular Manifestations in Alagille Syndrome -- The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development -- Skeletal Involvement in Alagille Syndrome -- Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype -- Health-Related Quality of Life and Neurocognition in Alagille Syndrome -- Future Therapeutic Approaches for Alagille Syndrome.
520			_aThis text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options. Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts. .
653		0	_aGastroenterology.
653		0	_aClinical medicine.
653		0	_aCardiology.
700	1		_aKamath, Binita M. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aLoomes, Kathleen M. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _9106996
776	0	8	_iPrinted edition: _z9783319945705
776	0	8	_iPrinted edition: _z9783319945729
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-94571-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0