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008			180131s2018 gw | s |||| 0|eng d
020			_a9783030818074
024	7		_a10.1007/978-3-030-81807-4 _2doi
040			_aES-MaUEC _bspa _dES-VaUE
050		4	_aRM300 _b.D78 2021 EB
245	1	0	_aDrug Delivery in Dermatology: _bFundamental and Practical Applications _cedited by Célia Luiza Petersen Vitello Kalil, Valéria Campos
250			_a1st ed. 2021
264		1	_aCham _bSpringer International Publishing _bImprint: Springer _c2021
300			_a1 recurso en línea (XIII, 208 páginas) _b2 b/w illustrations, 83 illustrations in colour
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
520	3		_aSkin accounts for approximately 15% of an adult’s total body weight, with a surface of about 2m². It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals. The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient.
650		7	_aSalud pública _2embne _9138408
650		7	_aCirugía _2embne _96789
650		0	_aDermatología _9515793 _xEnseñanza
700			_aPetersen Vitello Kalil, Célia Luiza _9517690
700			_aCampos, Valéria _9517691
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z978-3-030-81806-7
776	0	8	_iEdición impresa: _z978-3-030-81809-8
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-81807-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0