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020			_a9783030867058 ( _q) ( _qelectronic bk.)
020			_a3030867056 ( _q) ( _qelectronic bk.)
020			_z9783030867041
020			_z3030867048
024	7		_a10.1007/978-3-030-86705-8 _2doi
024	1		_aAU@ _b000070299271
040			_aYDX _beng _erda _epn _cUEV _dGW5XE _dEBLCP _dOCLCF
050			_aQR399 _b.C373 2022 EB
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100	1		_aCascella, Marco, _eauthor
245	1	0	_aFeatures and management of acute and chronic neuro-Covid _cMarco Cascella, Elvio De Blasio
264		1	_aCham _bSpringer _c[2022]
264		4	_c2022
300			_a1 online resource _billustrations (some color)
336			_atext _btxt [ _2rdacontent]
337			_acomputer _bc [ _2rdamedia]
338			_aonline resource _bcr [ _2rdacarrier]
504			_aIncludes bibliographical references
505	0		_aIntroduction -- Part I. Pathophysiology of COVID-19-associated neurotoxicity -- An update on preclinical findings -- Ongoing clinical investigations -- Perspectives -- Part II. Clinical manifestations of acute neurotoxicity -- Clinical features -- CNS complications -- PNS complications -- Diagnosis.-Management -- Perspectives -- Part III. Neurological and psychiatric sequelae in COVID-19 survivors.-Clinical features -- Neurological late complications -- psychological and psychiatric sequelae.-Diagnosis -- Tools -- The role of imaging -- Preventive strategies -- Social and economic impact.-Multidisciplinary management -- Perspectives
520			_aThis book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also be affected by infectious damage and clinical manifestations including Guillain-Barré syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients
650		0	_aCOVID-19 (Disease)- _xPathophysiology
650		0	_aNeurotoxicology
650		0	_aNeurologic manifestations of general diseases
650		7	_aNeurologic manifestations of general diseases.
650		7	_aNeurotoxicology.
655		0	_aElectronic books
700	1		_aDe Blasio, Elvio, _eauthor
776	0	8	_cOriginal _z3030867048 _z9783030867041 _w(OCoLC)1263339903
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-86705-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db