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008			130905s2013 xxu| s |||| 0|eng d
020			_a9781627034296
024	7		_a10.1007/978-1-62703-429-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-VaUE
050			_aQP623 _b2013 EB
245	1	4	_aThe Myc Gene _bMethods and Protocols _cedited by Laura Soucek, Nicole M. Sodir.
250			_a1st edition 2013
264		1	_aTotowa, NJ _bHumana Press _c2013
300			_a1 recurso en línea (XI, 282 páginas) _b44 ilustraciones, 29 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1012
505	0		_aThe Myc world within Reach -- Methods for the Expression, Purification, Preparation and Biophysical Characterization of Constructs of the c-Myc and Max b-HLH-LZs -- Analyzing Myc in Cell Transformation and Evolution -- Identifying Myc Interactors -- Detection of c-Myc Protein-Protein Interactions And Phosphorylation Status by Immunoprecipitation -- An Efficient Way of Studying Protein-Protein Interactions Involving HIF-α, c-Myc, and Sp1 -- Methods for Determining Myc-induced Apoptosis -- Methods to Study Myc-regulated Cellular Senescence -- Chromatin Immunoprecipitation Assays for Myc and N-Myc -- Methods to Quantify microRNAs in the Myc Gene Network for Posttranscriptional Gene Repression -- Genome-wide Analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA-binding by Next Generation Sequencing -- A High Throughput siRNA Screening Platform to Identify MYC Synthetic Lethal Genes as Candidate Therapeutic Targets -- Investigating Myc-dependent Translational Regulation in Normal and Cancer Cells -- Studying Myc's Role in Metabolism Regulation -- Generation of a Tetracycline Regulated Mouse Model of MYC-induced T-cell Acute Lymphoblastic Leukemia -- Methods to Assess Myc Function in Intestinal Homeostasis, Regeneration and Tumourigenesis -- Detection of c-myc Amplification in Formalin-fixed Paraffin-Embedded Tumor Tissue by Chromogenic in situ Hybridization (CIHS) -- Cell-Based Methods for the Identification of MYC-Inhibitory Small Molecules.
520			_aMyc controls multiple cellular functions, including cell proliferation, growth, differentiation and death, both directly and indirectly, through its modulation of downstream transcriptional programs. In The Myc Gene: Methods and Protocols, experts in the field summarize the standard and novel techniques that allow the studying of Myc mechanism of action in normal and cancer cells, in vitro and in vivo, in one succinct manual. Written in the highly successful Methods in Molecular Biology  series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
988			_aSpringer_Protocols_2013
650		7	_2embne _97393 _aBiología molecular
700	1		_aSoucek, Laura _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aSodir, Nicole M _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781627034302
776	0	8	_iPrinted edition: _z9781627034289
776	0	8	_iPrinted edition: _z9781493960170
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-62703-429-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db