000			03713nam a22003615i 4500
001			233200
003			ES-VaUE
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007			cr nn 008mamaa
008			200106s2020 xxu| s |||| 0|eng d
020			_a9781071601716
024	7		_a10.1007/978-1-0716-0171-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aImmuno-Oncology _bCellular and Translational Approaches _cedited by Seng-Lai Tan.
250			_a1st edition 2020
264		1	_aNew York, NY _bSpringer International Publising _c2020
300			_a1 recurso en línea (X, 262 páginas) _b91 ilustraciones, 83 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aAn In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies -- High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry -- In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis -- Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays -- Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates -- Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay -- 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment -- Considerations in Developing Reporter Gene Bioassays for Biologics -- Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies -- Precision Medicine: The Function of Receptor Occupancy in Drug Development -- In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics -- The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era.
520			_aThis book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics. The chapter "Considerations in Developing Reporter Gene Bioassays for Biologics" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
700	1		_aTan, Seng-Lai _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781071601709
776	0	8	_iPrinted edition: _z9781071601723
776	0	8	_iPrinted edition: _z9781071601730
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-0171-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2020
999			_c233200 _d233200