000			03969nam a22003615i 4500
001			233207
003			ES-VaUE
005			20221220020445.0
007			cr nn 008mamaa
008			200316s2020 xxu| s |||| 0|eng d
020			_a9781071603857
024	7		_a10.1007/978-1-0716-0385-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAnimal Models of Diabetes _bMethods and Protocols _cedited by Aileen J. F. King.
250			_a1st edition 2020
264		1	_aNew York, NY _bSpringer International Publising _c2020
300			_a1 recurso en línea (XI, 342 páginas) _b49 ilustraciones, 39 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2128
505	0		_aPractical Considerations when Using Mouse Models of Diabetes -- An Overview of Rodent Models of Obesity and Type 2 Diabetes -- Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice -- A Review of Mouse Models of Monogenic Diabetes and ER Stress Signalling -- Rat Models of Human Type 1 Diabetes -- Mouse Models of Autoimmune Diabetes: The Non-Obese Diabetic (NOD) Mouse -- Mouse Models of Virus-Induced Type 1 Diabetes -- Rat Models of Virus-Induced Type 1 Diabetes -- Large Animal Models of Diabetes -- Use of Streptozotocin in Rodent Models of Islet Transplantation -- Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging -- Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish -- Generating Beta-Cell Specific Transgenic Mice Using the Cre-Lox System -- The Glucose Tolerance Test in Mice -- Assessment of Insulin Tolerance In Vivo in Mice -- Continuous Glucose Monitoring in Conscious Unrestrained Mice -- Assessing Mouse Islet Function -- Assessing Immune Responses in the Nonobese Diabetic Mouse Model of Type 1 Diabetes -- Assessment of Insulin Tolerance Ex Vivo -- Using Pancreas Tissue Slices for the Study of Islet Physiology -- Determining Beta Cell Mass, Apoptosis, Proliferation, and Individual Beta Cell Size in Pancreatic Sections.
520			_aThis volume discusses a variety of animal models of diabetes, as well as describes techniques used to study end-points when using these models. The chapters in this book cover topics such as important considerations when working with mouse models of diabetes, highlighting factors that new investigators may not be aware of and some potential pitfalls in experimental outcomes; main characteristics of some commonly used animal models of diabetes research, ranging from mice to primates; animal models used to study specific aspects of beta-cell biology; and a focus on techniques used to assess blood glucose homeostasis, insulin action, and islet function in vivo and ex vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Animal Models of Diabetes: Methods and Protocols is a valuable resource that will help diabetes researchers design and carry out in vivo studies that will best suit their experimental questions and needs. .
700	1		_aKing, Aileen J. F _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781071603840
776	0	8	_iPrinted edition: _z9781071603864
776	0	8	_iPrinted edition: _z9781071603871
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-0385-7 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2020
999			_c233207 _d233207