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008			201214s2021 xxu| s |||| 0|eng d
020			_a9781071611548
024	7		_a10.1007/978-1-0716-1154-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAllostery _bMethods and Protocols _cedited by Luisa Di Paola, Alessandro Giuliani.
250			_a1st edition 2021
264		1	_aNew York, NY _bSpringer International Publising _c2021
300			_a1 recurso en línea (XII, 274 páginas) _b99 ilustraciones, 91 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2253
505	0		_aAllostery: The Rebound of Proteins -- Disclosing Allostery Through Protein Contact Networks -- Identification of Allosteric Effects in Proteins by Elastic Network Models -- Locating and Navigating Energy Transport Networks in Proteins -- Probing Allosteric Mechanism with Long-Range Rigidity Transmission across Protein Networks -- Protein Assembly: Defining the Strength of Protein-Protein Interactions Coupling the Theory with Experiments -- Network Re-Wiring during Allostery and Protein-Protein Interactions: A Graph Spectral Approach -- Topology Results on Adjacent Amino Acid Networks of Oligomeric Proteins -- Community Network Analysis of Allosteric Proteins -- The PyInteraph Workflow for the Study of Interaction Networks Form Protein Structural Ensembles -- The Allosteric Effect in Antibody-Antigen Recognition -- Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions -- Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Simulations -- Molecular Dynamics Simulation Techniques as a Tool in Drug Discovery and Pharmacology: A Focus on Allosteric Drugs -- Cooperativity and Allostery in RNA Systems.
520			_aThis volume explores the basic issues of "allostery" and "network" that are fundamental to studying this field. Chapters in this book look at how the basic "machine-like" proteins, that are similar to "human machines," need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of oscillating modes transversing the structure and underlying network wiring of the allosteric process; the "action at distance" by transduction of signals across an organized network structure; and the P53 protein located at the cross-road of cell cycle regulation, genome integrity, and cancer development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Allostery: Methods and Protocols is a valuable resource for any scientists and researcher interested in learning more about this developing field. .
700	1		_aDi Paola, Luisa _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGiuliani, Alessandro _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781071611531
776	0	8	_iPrinted edition: _z9781071611555
776	0	8	_iPrinted edition: _z9781071611562
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-1154-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2021
999			_c233406 _d233406