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007			cr nn 008mamaa
008			100318s2010 xxu| s |||| 0|eng d
020			_a9781603273671
024	7		_a10.1007/978-1-60327-367-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aGenetic Variation _bMethods and Protocols _cedited by Michael R. Barnes, Gerome Breen.
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XI, 388 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v628
505	0		_aGenetic Variation Analysis for Biomedical Researchers: A Primer -- Exploring the Landscape of the Genome -- Asking Complex Questions of the Genome Without Programming -- Laboratory Methods for the Detection of Chromosomal Abnormalities -- Cancer Genome Analysis Informatics -- Copy Number Variations in the Human Genome and Strategies for Analysis -- A Short Primer on the Functional Analysis of Copy Number Variation for Biomedical Scientists -- Computational Methods for the Analysis of Primate Mobile Elements -- Laboratory Methods for the Analysis of Primate Mobile Elements -- Practical Informatics Approaches to Microsatellite and Variable Number Tandem Repeat Analysis -- Assessing the Impact of Genetic Variation on Transcriptional Regulation In Vitro -- Whole Genome Sequencing -- Detection of Mitochondrial DNA Variation in Human Cells -- An Introduction to Mitochondrial Informatics -- Web-Based Analysis of (Epi-) Genome Data Using EpiGRAPH and Galaxy -- Short Tandem Repeats and Genetic Variation -- Bioinformatic Tools for Identifying Disease Gene and SNP Candidates -- Analysis of the Impact of Genetic Variation on Human Gene Expression -- Quality Control for Genome-Wide Association Studies -- Gaining a Pathway Insight into Genetic Association Data.
520			_aWith the continuing advances in sequencing technologies and the availability of thousands of distinct human genomes, we are fast approaching the day when "personal genomes" become a standard study measure and a routine component of personal health records. In Genetic Variation: Methods and Protocols, expert researchers address the rising importance of genome variation, both at the level of the individual and in population-based studies of disease, with a collection of detailed protocols reflecting the nature and impact of genetic variation on human phenotypes. The contributions cover a majority of the most important forms of genetic variation studied today, including single nucleotide polymorphisms (SNPs), insertions/deletion (indels), copy number variation (CNVs), variable number tandem repeats (VNTRs), mitochondrial variation, mobile elements, and epigenetic variation. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Convenient and cutting-edge, Genetic Variation: Methods and Protocols aims to bring bench scientists, clinicians, and bioinformaticians together in order to aid progress toward a greater understanding of the full impact of variation on human health and disease.
700	1		_aBarnes, Michael R _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBreen, Gerome _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607616559
776	0	8	_iPrinted edition: _z9781603273664
776	0	8	_iPrinted edition: _z9781627038263
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-367-1 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2010
999			_c233558 _d233558