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020			_a9781071614884
024	7		_a10.1007/978-1-0716-1488-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aSepsis _bMethods and Protocols _cedited by Wendy E. Walker.
250			_a1st edition 2021
264		1	_aNew York, NY _bSpringer International Publising _c2021
300			_a1 recurso en línea (XIII, 262 páginas) _b53 ilustraciones, 50 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2321
505	0		_aCecal Ligation and Puncture -- Colon Ascendens Stent Peritonitis (CASP) -- Induction of Sepsis via Fibrin Clot Implantation -- Cecal Slurry Injection in Neonatal and Adult Mice -- Injection of Escherichia coli to Induce Sepsis -- A Mouse Model of Pseudomonas aeruginosa Pneumonia -- A Mouse Model of Candidiasis -- Francisella tularensis Infection of Mice as a Model of Sepsis -- A Mouse Model of Necrotizing Enterocolitis -- A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection -- Mouse Intensive Care Unit (MICU) -- Creation of BLT Humanized Mice for Sepsis Studies -- Scoring Sepsis Severity in Mice,0 Identification of ILC2 in the Lung Using Flow Cytometry -- Measurement of Intestinal Permeability During Sepsis -- Sepsis Biomarkers -- Detection of Blood Cell Surface Biomarkers in Septic Mice -- Microfluidic Chips for Sepsis Diagnosis -- Analgesia and Humane Endpoints for Rodents in Sepsis Research -- Agent-Based Modeling of Systemic Inflammation: A Pathway towards Controlling Sepsis.
520			_aThis detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical rodent models of sepsis, presented by experts in the field. In addition, the book includes protocols for burn injury and sepsis, modeling the mouse intensive care unit (MICU), and the development of humanized mice, which may be useful tools to increase the translational potential of rodent sepsis research. There is a chapter discussing the use of biomarkers for sepsis diagnosis and prognosis in humans and mice, as well as chapters describing specific methods for biomarker measurement, and the use of analgesics and humane endpoints in rodent sepsis research. Finally, agent-based computational modeling is presented as a valuable complementary approach to study sepsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sepsis: Methods and Protocols serves as an ideal guide for researchers working toward improving the identification and treatment of septic patients.
700	1		_aWalker, Wendy E _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781071614877
776	0	8	_iPrinted edition: _z9781071614891
776	0	8	_iPrinted edition: _z9781071614907
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-1488-4 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2021
999			_c233580 _d233580