000			03216nam a22003615i 4500
001			233660
003			ES-VaUE
005			20221220020514.0
007			cr nn 008mamaa
008			180606s2018 xxu| s |||| 0|eng d
020			_a9781493978687
024	7		_a10.1007/978-1-4939-7868-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aGenetic Epidemiology _bMethods and Protocols _cedited by Evangelos Evangelou.
250			_a1st edition 2018
264		1	_aNew York, NY _bSpringer International Publishing _c2018
300			_a1 recurso en línea (X, 299 páginas) _b35 ilustraciones, 23 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1793
505	0		_aIntroduction to Epidemiological Studies -- Key Concepts in Genetic Epidemiology -- Quality Control of Common and Rare Variants -- Genome Wide Association Studies -- Assessing Rare Variation in Complex Traits -- Meta-analysis of Common and Rare Variants -- Gene-gene and Gene-environment Interactions -- Genetic Association in the HLA Region -- Novel Methods for Family-based Genetic Studies -- Methods for Polygenic Traits -- Multivariate Methods for Meta-analysis of Genetic Association Studies -- Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes -- A Primer in Mendelian Randomization Methodology with a Focus on Utilizing Published Summary Association Data -- Copy Number Variation -- From Identification to Function: Current Strategies to Prioritise and Follow-Up GWAS Results -- Translating Human Genetics into Novel Drug Targets.
520			_aThis volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
700	1		_aEvangelou, Evangelos _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493978670
776	0	8	_iPrinted edition: _z9781493978694
776	0	8	_iPrinted edition: _z9781493993093
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-7868-7 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2018
999			_c233660 _d233660