000			03901nam a22003615i 4500
001			233747
003			ES-VaUE
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007			cr nn 008mamaa
008			100301s2004 xxu| s |||| 0|eng d
020			_a9781592594290
024	7		_a10.1385/1592594298 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aSuicide Gene Therapy _bMethods and Reviews _cedited by Caroline J. Springer.
250			_a1st edition 2004
264		1	_aTotowa, NJ _bHumana Press _c2004
300			_a1 recurso en línea (XIV, 555 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v90
505	0		_ato the Background, Principles, and State of the Art in Suicide Gene Therapy -- to Vectors for Suicide Gene Therapy -- Construction of VNP20009 -- Nonreplicating DNA Viral Vectors for Suicide Gene Therapy -- Replication-Selective Oncolytic Adenoviruses -- Retroviral Vectors for Suicide Gene Therapy -- Nonviral Liposomes -- Peptide- and Polymer-Based Gene Delivery Vehicles -- Design of Prodrugs for Suicide Gene Therapy -- Cytochrome P450-Based Gene Therapies for Cancer -- Tumor Sensitization to Purine Analogs by E. coli PNP -- Enzyme-Prodrug Systems -- Enzyme-Prodrug Systems -- Methods to Improve Efficacy in Suicide Gene Therapy Approaches -- Extracellular ?-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy -- Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis -- Combination Suicide Gene Therapy -- Immune Response to Suicide Gene Therapy -- Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus -- Radiation-Activated Antitumor Vectors -- In Vitro and In Vivo Models for Evaluation of GDEPT -- Suicide Gene Therapy in Liver Tumors -- Clinical Trials With GDEPT -- The Nitroreductase/CB1954 Enzyme-Prodrug System -- Side Effects of Suicide Gene Therapy -- Antibody-Directed Enzyme-Prodrug Therapy -- Bioreductive Prodrugs for Cancer Therapy.
520			_aSuicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.
700	1		_aSpringer, Caroline J _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617372834
776	0	8	_iPrinted edition: _z9780896039711
776	0	8	_iPrinted edition: _z9781489939364
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592594298 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2004
999			_c233747 _d233747