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001			233748
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008			100301s2004 xxu| s |||| 0|eng d
020			_a9781592596515
024	7		_a10.1385/1592596517 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aIn Vitro Neurotoxicology _bPrinciples and Challenges _cedited by Evelyn Tiffany-Castiglioni.
250			_a1st edition 2004
264		1	_aTotowa, NJ _bHumana Press _c2004
300			_a1 recurso en línea (XV, 331 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aIn Vitro Neurotoxicology -- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment -- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics -- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis -- Role of Apoptosis in Neurotoxicology -- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants -- Cell-Type Specific Responses of the Nervous System to Lead -- Effects of Toxicants on Neural Differentiation -- Impairment of Synaptic Function by Exposure to Lead -- Aggregating Brain Cell Cultures for Neurotoxicological Studies -- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors -- Establishing In Vitro Models to Study Endogenous Neurotoxicants.
520			_aNeurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants. Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing.
700	1		_aTiffany-Castiglioni, Evelyn _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617373237
776	0	8	_iPrinted edition: _z9781588290472
776	0	8	_iPrinted edition: _z9781489939647
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592596517 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2004
999			_c233748 _d233748