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008			161125s2017 xxu| s |||| 0|eng d
020			_a9781493966615
024	7		_a10.1007/978-1-4939-6661-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aStem Cell-Derived Models in Toxicology _cedited by Mike Clements, Liz Roquemore.
250			_a1st edition 2017
264		1	_aNew York, NY _bSpringer International Publishing _c2017
300			_a1 recurso en línea (XII, 341 páginas) _b124 ilustraciones, 108 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aStem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the "Proclinical Space" -- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk -- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology -- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes -- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential -- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions -- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems -- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes -- Decoding Ca2+ Signals as a Non-Electrophysiological Method for Assessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes -- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes -- Edge Detection for Contractility Measurements with Cardiac Spheroids -- Contractile Force Readout of hESC-Cardiomyocytes -- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models -- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes -- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA) -- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies.
520			_aThis detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
700	1		_aClements, Mike _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRoquemore, Liz _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493966592
776	0	8	_iPrinted edition: _z9781493966608
776	0	8	_iPrinted edition: _z9781493982646
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-6661-5 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2017
999			_c233763 _d233763