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007			cr nn 008mamaa
008			160505s2016 xxu| s |||| 0|eng d
020			_a9781493936618
024	7		_a10.1007/978-1-4939-3661-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMouse Models for Drug Discovery _bMethods and Protocols _cedited by Gabriele Proetzel, Michael V. Wiles.
250			_a2nd edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 436 páginas) _b63 ilustraciones, 37 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1438
505	0		_aGenetically Defined Strains in Drug Development and Toxicity Testing -- Simple, Efficient CRISPR-Cas9 Mediated Gene Editing in Mice: Strategies and Methods -- Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice -- Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells -- Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens -- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies -- A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics -- Germ-Free Mice Model for Studying Host-Microbial Interactions -- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans -- Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery -- Cholesterol Absorption and Metabolism -- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening -- Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research -- Murine Model for Colitis-Associated Cancer of the Colon -- Mouse Models for Studying Depression-Like States and Antidepressant Drugs -- Experimental Models of Anxiety for Drug Discovery and Brain Research -- Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders -- Better Utilization of Mouse Models of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the Clinic -- Neuromuscular Disease Models and Analysis -- Brightfield Imaging and Optical Coherence Tomography of the Mouse Posterior Eye -- Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.
520			_aWith genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.
700	1		_aProetzel, Gabriele _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aWiles, Michael V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493936595
776	0	8	_iPrinted edition: _z9781493936601
776	0	8	_iPrinted edition: _z9781493981090
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-3661-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c233769 _d233769