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008			110829s2011 xxu| s |||| 0|eng d
020			_a9781617792762
024	7		_a10.1007/978-1-61779-276-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aNetwork Biology _bMethods and Applications _cedited by Gerard Cagney, Andrew Emili.
250			_a1st edition 2011
264		1	_aTotowa, NJ _bHumana Press _c2011
300			_a1 recurso en línea (XV, 437 páginas) _b85 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v781
505	0		_aAnalysis of Protein-Protein Interactions Using High-throughput Yeast Two-Hybrid Screens -- Identification of Mammalian Protein Complexes by Lentiviral-Based Affinity Purification and Mass Spectrometry -- Protein Networks Involved in Vesicle Fusion, Transport, and Storage Revealed by Array-Based Proteomics -- Identification and Relative Quantification of Native and Proteolytically Generated Protein C-termini from Complex Proteomes: C-terminome Analysis -- Construction of Protein Interaction Networks Based on the Label Free Quantitative Proteomics -- Studying Binding Specificities of Peptide Recognition Modules by High-Throughput Phage Display Selections -- Array-Based Synthetic Genetic Screens to Map Bacterial Pathways and Functional Networks in Escherichia coli -- Advanced Methods for High-Throughput Microscopy Screening of Genetically Modified Yeast Libraries -- Pooled Lentiviral shRNA Screening for Functional Genomics in Mammalian Cells -- Plant DNA Sequencing for Phylogenetic Analyses: From Plants to Sequences -- Using Coevolution to Predict Protein-Protein Interactions -- Visualizing Gene-Set Enrichment Results Using the Cytoscape Plugin Enrichment Map -- Quality Control Methodology for High-Throughput Protein-Protein Interaction Screening -- Filtering and Interpreting Large-Scale Experimental Protein-Protein Interaction Data -- Classification of Cancer Patients Using Pathway Analysis and Network Clustering -- Statistical Analysis of Dynamic Transcriptional Regulatory Network Structure -- Imputing and Predicting Quantitative Genetic Interactions in Epistatic MAPs -- Displaying Chemical Information on a Biological Network Using Cytoscape -- Modeling of Proteins and Their Assemblies with the Integrative Modeling Platform -- Predicting Node Characteristics from Molecular Networks -- Mathematical Modeling of Biomolecular Network Dynamics.
520			_aWhile extremely large datasets describing gene sequences, mRNA transcripts, protein abundance, and metabolite concentrations are increasingly commonplace, these represent only starting 'parts lists' that are usually insufficient to unlock mechanistic insights on their own right.  Fortunately, as Network Biology: Methods and Applications examines, concepts emerging from the study of biological entities such as networks (e.g. functional interactions linking genes, proteins, metabolites, etc.) suggest that order rather than chaos prevails, with such principles as modular and hierarchical organization, reactive information-driven causal-response behaviours, systems robustness, co-evolution, and self-organization guiding the way.  This volume presents detailed, practical descriptions of the experimental and computational approaches currently prevalent in network biology as written by practiced experts in the field.  Written in the highly successful Methods in Molecular Biology™ series format, relevant chapters contain introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.   Comprehensive and accessible, Network Biology: Methods and Applications provides an ensemble of procedures that will be of great value to a broad assortment of readers, ranging from graduate students to seasoned professionals looking to polish their skill sets.
700	1		_aCagney, Gerard _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aEmili, Andrew _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617792755
776	0	8	_iPrinted edition: _z9781617792779
776	0	8	_iPrinted edition: _z9781493958559
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-276-2 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2011
999			_c233790 _d233790