000			03717nam a22003615i 4500
001			233803
003			ES-VaUE
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007			cr nn 008mamaa
008			100301s2000 xxu| s |||| 0|eng d
020			_a9781592590759
024	7		_a10.1385/1592590756 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aDrug Targeting _bStrategies, Principles, and Applications _cedited by G. E. Francis.
250			_a1st edition 2000
264		1	_aTotowa, NJ _bHumana Press _c2000
300			_a1 recurso en línea (X, 318 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v25
505	0		_aStrategies -- Chemical Construction of Immunotoxins -- Construction of Ribonuclease-Antibody Conjugates for Selective Cytotoxicity -- Intracellular Targeting Using Bispecific Antibodies -- Antibody Conjugation Methods for Active Targeting of Liposomes -- Folate as a Targeting Device for Proteins Utilizing Folate Receptor-Mediated Endocytosis -- Preparation of Recombinant RNase Single-Chain Antibody Fusion Proteins -- Theoretical Aspects -- Practical Considerations in the Exploitation of Passive Tumor Targeting -- Effect of Dose, Molecular Size, and Binding Affinity on Uptake of Antibodies -- Inhibition of Tumor Blood Flow -- Applications -- 10 Targeting in Myocardial Infarction -- 11 Targeting HIV-Infected Cells -- 12 Making Fusion Toxins to Target Leukemia and Lymphoma -- Antibody-Bearing Liposomes as Chloroquine Vehicles in Treatment of Murine Malaria -- 14 Immunotargeting of Catalase to the Pulmonary Vascular Endothelium -- 15 Targeted Gene Transfer.
520			_aIn Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies. In addition to providing detailed step-by-step instructions, the highly experienced authors review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also presented are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium, as well as methods addressing both the active and passive targeting of tumors. Comprehensive and innovative, Drug Targeting: Strategies, Methods, and Protocols documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.
700	1		_aFrancis, G. E _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781489941718
776	0	8	_iPrinted edition: _z9780896035317
776	0	8	_iPrinted edition: _z9781489941701
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592590756 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2000
999			_c233803 _d233803