000			04006nam a22003855i 4500
001			233806
003			ES-VaUE
005			20221220020522.0
007			cr nn 008mamaa
008			100301s1988 xxu| s |||| 0|eng d
020			_a9781592596157
024	7		_a10.1385/0896031217 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAnalysis of Psychiatric Drugs _cedited by Alan A. Boulton, Glen B. Baker, Ronald T. Coutts.
250			_a1st edition 1988
264		1	_aTotowa, NJ _bHumana Press _c1988
300			_a1 recurso en línea (XX, 547 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v10
505	0		_aProtein Binding of Psychotropic Drugs -- Isotope Derivative Assays for Psychotropic Drugs -- Gas-Liquid Chromatography of Antidepressant, Antipsychotic, and Benzodiazepine Drugs in Plasma and Tissues -- Gas Chromatographic- Mass Spectrometric Analysis of Antidepressants, Neuroleptics, and Benzodiazepines -- High-Performance Liquid Chromatographic Analysis of Antidepressants, Neuroleptics, and Benzodiazepines -- Principles of Radioreceptor Assays -- Application of Immunoassay Techniques in Psychopharmacology -- Drug Screening for Benzodiazepines, Antidepressants, and Neuroleptics -- In Vitro and Ex Vivo Neurochemical Screening Procedures for Antidepressants Neuroleptics Benzodiazepines -- Animal Models for Assessing Anxiolytic, Neuroleptic, and Antidepressant Drug Action -- High-Affinity Binding of Antidepressants to Platelets and Brain Tissues -- Structure-Activity Relationships at the Benzodiazepine Receptor.
520			_aIn this volume, we hope to cover the malor techniques that are presently being used to analyze the actions of drugs used in psyc- atry. The contributors of the chapters are active researchers who have considerable practical experience with the techniques they are describing, and the emphasis in the chapters is on three types of psychiatric drugs, namely antidepressants, antipsychotics, and anxiolytics. The first chapter, by Curry and Yu, discusses protein binding of psychotropic drugs, with special reference to equilibrium ana- sis as the method of assessment and to lipophilicity correlations. Since many of the drugs used in treating psychiatric disorders are bound extensively to protein, this aspect is of great importance with regard to their therapeutic actions and toxicity, Basic mat- matical models, techniques for the study of protein binding, molecular aspects of protein binding, binding in relation to lipophilicity, indirect approaches to measurement of the fraction of drug bound, the function of protein binding, and tissue binding are among the topics discussed. Chapter 2, by Norman and B- rows, deals with the principles of isotope derivative assays and their applications to antidepressants and antipsychotics; extensive protocols are provided. The third chapter, by Cooper, deals with analysis by gas-liquid chromatography. Sample collection and storage, extraction procedures, column selection, use of internal standards, types of detectors, techniques of application, and - plications to specific drugs are among the topics discussed.
700	1		_aBoulton, Alan A _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBaker, Glen B _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aCoutts, Ronald T _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781489941091
776	0	8	_iPrinted edition: _z9780896031210
776	0	8	_iPrinted edition: _z9781489941084
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/0896031217 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_1988
999			_c233806 _d233806