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008			100715s2009 xxu| s |||| 0|eng d
020			_a9781607612476
024	7		_a10.1007/978-1-60761-247-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aCardiovascular Genomics _bMethods and Protocols _cedited by Keith DiPetrillo.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (X, 350 páginas) _b84 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v573
505	0		_aModes of Defining Atherosclerosis in Mouse Models: Relative Merits and Evolving Standards -- Evaluating Micro- and Macro-vascular Disease, the End Stage of Atherosclerosis, in Rat Models -- Non-invasive Blood Pressure Measurement in Mice -- Direct Blood Pressure Monitoring in Laboratory Rodents via Implantable Radio Telemetry -- Measuring Kidney Function in Conscious Mice -- Ischemic Stroke in Mice and Rats -- Mouse Surgical Models in Cardiovascular Research -- Echocardiographic Examination in Rats and Mice -- QTL Mapping in Intercross and Backcross Populations -- Quantitative Trait Locus Analysis Using J/qtl -- Computing Genetic Imprinting Expressed by Haplotypes -- Haplotype Association Mapping in Mice -- Candidate Gene Association Analysis -- Genome-Wide Association Study in Humans -- Bioinformatics Analysis of Microarray Data -- eQTL Analysis in Mice and Rats -- eQTL Analysis in Humans -- A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation.
520			_aAs two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
700	1		_aDiPetrillo, Keith _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607612483
776	0	8	_iPrinted edition: _z9781607612469
776	0	8	_iPrinted edition: _z9781617796432
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-247-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c233820 _d233820