000			03318nam a22003615i 4500
001			233850
003			ES-VaUE
005			20221220020525.0
007			cr nn 008mamaa
008			100715s2009 xxu| s |||| 0|eng d
020			_a9781607612742
024	7		_a10.1007/978-1-60761-274-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aChemogenomics _bMethods and Applications _cedited by Edgar Jacoby.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (X, 320 páginas) _b107 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v575
505	0		_aOrganizing Bioactive Compound Discovery in Target Families -- Compound Library Design for Target Families -- Targeting the Purinome -- Cofactor Chemogenomics -- Chemogenomics with Protein Secondary-Structure Mimetics -- Database Systems for Knowledge-Based Discovery -- Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein Interaction -- Off-Target Networks Derived from Ligand Set Similarity -- Chemogenomic Analysis of Safety Profiling Data -- Network and Pathway Analysis of Compound-Protein Interactions -- The Flexible Pocketome Engine for Structural Chemogenomics -- Structure-Based Chemogenomics: Analysis of Protein Family Landscapes -- Hypothesis-Driven Screening.
520			_aThe establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology™ series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.
700	1		_aJacoby, Edgar _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607612759
776	0	8	_iPrinted edition: _z9781607612735
776	0	8	_iPrinted edition: _z9781617796395
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-274-2 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c233850 _d233850