000			04043nam a22003615i 4500
001			233867
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007			cr nn 008mamaa
008			151012s2016 xxu| s |||| 0|eng d
020			_a9781493927548
024	7		_a10.1007/978-1-4939-2754-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aEpigenetic Methods in Neuroscience Research _cedited by Nina Karpova.
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XII, 258 páginas) _b43 ilustraciones, 37 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v105
505	0		_aEpigenetics: From Basic Biology To Chromatin Modifying Drugs And New Potential Clinical Applications -- Analysis Of Brain Epigenome: A Guide To Epigenetic Methods -- Analysis Of DNA Methylation By Bisulfite Reaction In Neural Cells As An Example Of Orexin Neurons -- Protocol For The Simultaneous Analysis Of Gene DNA Methylation And Mrna Expression Levels In The Rodent Brain -- Simultaneous Quantification Of Global 5mc And 5hmc Levels In The Nervous System Using A HPLC/MS Method -- Protocol For Methylated DNA Immunoprecipitation (Medip) Analysis -- Cell Type-Specific DNA Methylation Analysis In Neurons And Glia -- Immunohistochemical Detection Of Oxidized Forms Of 5-Methylcytosine In Embryonic And Adult Brain Tissue -- Analysis Of Histone Modifications In Neural Cells As An Example Of Orexin Neurons -- Site-Specific Delivery Of Epigenetic Modulating Drugs Into The Rat Brain -- Mammalian Genome Plasticity: Expression Analysis Of Transposable Elements -- Tools For Analyzing The Role Of Local Protein Synthesis In Synaptic Plasticity -- In Situ Detection Of Neuron-Specific Micrornas In Frozen Brain Tissue Meister -- Protocol For High-Throughput Mirna Profiling Of The Rat Brain -- Metabolites As Clock Hands: Estimation Of Internal Body Time Using Blood Metabolomics.
520			_aThis volume presents state-of-the-art methods for reliable detection of epigenetic changes in the nervous system. Epigenetic Methods in Neuroscience Research  guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples; sensitive method for quantification of alternative methylated forms of cytosines by liquid chromatography/mass spectrometry; affinity-based detection of modified cytosines by immunohistochemistry or methylated DNA immunoprecipitation; chromatin immunoprecipitation, or ChIP; miRNA high-throughput profiling and the in situ detection of miRNA subtle expression in the brain; analysis of genes with alternative 3'UTRs; and the cite-specific delivery of chromatin-modifying drugs. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.    Concise and easy-to-use, Epigenetic Methods in Neuroscience Research provides multidisciplinary epigenetic approach to study genome, and neural, plasticity that will help the reader to successfully address the challenges associated with neurodevelopmental, psychiatric, and neurodegenerative disorders.
700	1		_aKarpova, Nina _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493927531
776	0	8	_iPrinted edition: _z9781493927555
776	0	8	_iPrinted edition: _z9781493949410
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2754-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c233867 _d233867