000			03972nam a22003855i 4500
001			233886
003			ES-VaUE
005			20221220020528.0
007			cr nn 008mamaa
008			100301s1992 xxu| s |||| 0|eng d
020			_a9781592596256
024	7		_a10.1385/0896032078 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aIntracellular Messengers _cedited by Alan A. Boulton, Glen B. Baker, Colin W. Taylor.
250			_a1st edition 1992
264		1	_aTotowa, NJ _bHumana Press _c1992
300			_a1 recurso en línea (XIX, 580 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v20
505	0		_aIdentification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue -- Methods for the Analysis of Phosphoinositides and Inositol Phosphates -- Inositol Triphosphate Receptors and Intracellular Calcium -- Measurement of Intracellular Calcium with Fluorescent Calcium Indicators -- Single-Cell Imaging Technology -- Analysis of Protein Kinase C Function -- Synthetic Analogs of Intracellular Messengers -- Methods in Cyclic Nucleotide Research -- Caged Intracellular Messengers and the Inositol Phosphate Signaling Pathway -- Protein Phosphorylation -- Investigation of the Intracellular Regulators and Components of the Exocytotic Pathway -- Intracellular Messengers in Vertebrate Photoreceptors -- Intracellular Messengers in Invertebrate Photoreceptors Studied in Mutant Flies.
520			_aDespite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.
700	1		_aBoulton, Alan A _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBaker, Glen B _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aTaylor, Colin W _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781489940278
776	0	8	_iPrinted edition: _z9780896032071
776	0	8	_iPrinted edition: _z9781489940261
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/0896032078 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_1992
999			_c233886 _d233886