000			03601nam a22003615i 4500
001			233889
003			ES-VaUE
005			20221220020528.0
007			cr nn 008mamaa
008			110428s2009 xxu| s |||| 0|eng d
020			_a9781597454292
024	7		_a10.1007/978-1-59745-429-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMacromolecular Drug Delivery _bMethods and Protocols _cedited by Mattias Belting.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (XIV, 205 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v480
505	0		_aDevelopments in Macromolecular Drug Delivery -- Synthetic vs. Natural/Biodegradable Polymers for Delivery of shRNA-Based Cancer Therapies -- siRNA and DNA Transfer to Cultured Cells -- Poly(?-amino esters): Procedures for Synthesis and Gene Delivery -- Systemic Delivery and Pre-clinical Evaluation of Nanoparticles Containing Antisense Oligonucleotides and siRNAs -- Peptide-Based Delivery of Steric-Block PNA Oligonucleotides -- Characterizing Peptide-Mediated DNA Internalization in Human Cancer Cells -- Selection and Characterization of Antibodies from Phage Display Libraries Against Internalizing Membrane Antigens -- Artificial Membrane Models for the Study of Macromolecular Delivery -- Enhanced Delivery of Macromolecules into Cells by Electroendocytosis -- In Vitro Systems for Studying Epithelial Transport of Macromolecules -- Preparation of Macromolecule-Containing Dry Powders for Pulmonary Delivery -- Macromolecular Delivery Across the Blood-Brain Barrier -- Positron Emission Tomography (PET) and Macromolecular Delivery In Vivo.
520			_aMacromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
700	1		_aBelting, Mattias _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607610298
776	0	8	_iPrinted edition: _z9781588299994
776	0	8	_iPrinted edition: _z9781627039666
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-429-2 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c233889 _d233889